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Limitations of Vancomycin in the Management of Resistant Staphylococcal Infections
Abstract
Vancomycin is effective against methicillin-resistant Staphylococcus aureus and has been widely used in the past few years. However, several recent reports have highlighted the limitations of vancomycin, and its role in the management of serious infections is now being reconsidered. Vancomycin treatment failure rates are associated with an increase in the minimum inhibitory concentration as well as a decrease in the rate of bacterial killing. The intrinsic limitations of vancomycin also include poor tissue penetration, particularly in the lung; relatively slow bacterial killing; and the potential for toxicity. In addition, intermediate-level vancomycin resistance has emerged among staphylococci, as have rare cases of fully resistant strains. Because of these problems, when using vancomycin, it is probably prudent to carefully establish the diagnosis, test for antimicrobial susceptibility, and monitor serum trough concentrations to ensure adequate dosing.
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Citations
Cited by
Riedel, D. J., Weekes, E., & Forrest, G. N. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00300-08 · Cited by 136
Jang, H., Kim, S., Kim, K. H., Kim, C. J., Lee, S., Song, K., Jeon, J. H., Park, W. B., Kim, H. B., Park, S., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/600295 · Cited by 113
Metadata
- Authors
- Kollef, M. H.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09-15
- Volume
- 45
- Issue
- Supplement_3
- Pages
- S191-S195
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W1981637228
- Cited by
- 178
- References
- 0
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kollef, M. H. (2007). Limitations of Vancomycin in the Management of Resistant Staphylococcal Infections. Clinical Infectious Diseases. https://doi.org/10.1086/519470
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
