Emergence of Candida parapsilosis as the Predominant Species Causing Candidemia in Children
Abstract
An increase in the rate of isolation of Candida parapsilosis, relative to other Candida species, in our children's hospital led us to analyze the clinical and epidemiological variables associated with candidemia. We sought to determine if these variables are different for patients infected with C. parapsilosis. All episodes of candidemia occurring over a 7-year period were analyzed retrospectively. Of 81 episodes in 80 patients, 35 (43%) were in neonates, and 46 (57%) were in nonneonates. C. parapsilosis was isolated in 40 episodes (49%). C. parapsilosis was significantly more likely than non-C. parapsilosis species to be associated with prematurity (P = .001), presence of a central venous catheter (P = .002), and use of total parenteral nutrition (P = .03). C. parapsilosis has emerged as the predominant species in our children's hospital. The mortality rate associated with candidemia in children is lower than previously reported and may be associated with the high rate of isolation of C. parapsilosis.
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Candidemia due to C. parapsilosis has increased in frequency in pediatric populations and appears to be associated with a lower mortality rate than is candidemia due to other species of Candida.
“Candidemia due to C. parapsilosis has increased in frequency in pediatric populations and appears to be associated with a lower mortality rate than is candidemia due to other species of Candida [110-113].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [110]
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References 13 · Cited by 210
- Authors
- Levy, I., Rubin, L. G., Vasishtha, S., Tucci, V., & Sood, S. K.
- Affiliations
- Schneider Children's Hospital (US)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Sood, Sunil K.
- ORCID
- Rubin, Lorry G.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-05
- Volume
- 26
- Issue
- 5
- Pages
- 1086-1088
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2105896831
- Cited by
- 210
- References
- 13
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 9 · 2015: 2 · 2014: 10 · 2013: 7 · 2012: 13
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida parapsilosis, candidemia, pediatric candidiasis, neonates, risk factors, preterm birth, central venous catheters, total parenteral nutrition, mortality, Candida species distribution
- MeSH terms
- Adolescent, Adult, Candida, Candidiasis, Catheterization, Central Venous, Child, Child, Preschool, Female, Hospitals, Urban, Humans, Infant, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Male, New York, Parenteral Nutrition, Total, Retrospective Studies, Causality, Fungemia
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