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Staphylococcus aureus: A Well–Armed Pathogen
Abstract
Staphylococcus aureus is a virulent pathogen that is currently the most common cause of infections in hospitalized patients. S. aureus infection can involve any organ system. The success of S. aureus as a pathogen and its ability to cause such a wide range of infections are the result of its extensive virulence factors. The increase in the resistance of this virulent pathogen to antibacterial agents, coupled with its increasing prevalence as a nosocomial pathogen, is of major concern. The core resistance phenotype that seems to be most associated with the persistence of S. aureus in the hospital is methicillin resistance. Methicillin resistance in nosocomial S. aureus isolates has been increasing dramatically in United States hospitals and is also associated with resistance to other useful antistaphylococcal compounds. Possible ways to decrease the incidence of nosocomial S. aureus infections include instituting more effective infection control, decreasing nasal colonization, developing vaccines, and developing new or improved antimicrobials.
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Cited by
Lina, G., Piemont, Y., Godail-Gamot, F., Bes, M., Peter, M.-O., Gauduchon, V., Vandenesch, F., & Etienne, J. (1999) · Clinical Infectious Diseases · doi:10.1086/313461 · Cited by 2,489
Methicillin-Resistant Staphylococcus aureus Disease in Three Communities
Fridkin, S. K., Hageman, J. C., Morrison, M., Sanza, L. T., Como-Sabetti, K., Jernigan, J. A., Harriman, K., Harrison, L. H., Lynfield, R., & Farley, M. M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043252 · Cited by 1,493
Dale, S. E., Doherty-Kirby, A., Lajoie, G., & Heinrichs, D. E. (2004) · Infection and Immunity · doi:10.1128/iai.72.1.29-37.2004 · Cited by 232
Small, C.-L., Shaler, C. R., McCormick, S., Jeyanathan, M., Damjanovic, D., Brown, E. G., Arck, P., Jordana, M., Kaushic, C., Ashkar, A. A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902772 · Cited by 216
Involvement of SirABC in Iron-Siderophore Import in Staphylococcus aureus
Dale, S. E., Sebulsky, M. T., & Heinrichs, D. E. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.24.8356-8362.2004 · Cited by 132
Metadata
- Authors
- Archer, G. L.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-05
- Volume
- 26
- Issue
- 5
- Pages
- 1179-1181
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2142257083
- Cited by
- 658
- References
- 0
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Archer, G. L. (1998). Staphylococcus aureus: A Well–Armed Pathogen. Clinical Infectious Diseases. https://doi.org/10.1086/520289
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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