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Fluid Replacement in Dengue Shock Syndrome: A Randomized, Double‐Blind Comparison of Four Intravenous‐Fluid Regimens
Abstract
Dengue hemorrhagic fever and dengue shock syndrome (DSS) are major causes of childhood morbidity and mortality in many tropical countries. Increased intravascular permeability leading to shock is the cardinal feature of DSS. Fluid resuscitation to counteract massive plasma leakage is the mainstay of treatment. A double-blind, randomized trial comparing four intravenous-fluid regimens for acute resuscitation of 50 children with DSS was conducted. Colloids (dextran 70 or the protein digest gelafundin 35,000) restored cardiac index and blood pressure and normalized hematocrit more rapidly than crystalloids (Ringer's lactate or 0.9%-weight/volume saline). Dextran 70 provided the most rapid normalization of the hematocrit and restoration of the cardiac index, without adverse effects, and may be the preferred solution for acute resuscitation in DSS. Further large-scale double-blind trials are required to provide an evidence-based approach to the management of DSS.
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Cited by
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694
European Resuscitation Council Guidelines for Resuscitation 2015
Monsieurs, K. G., Nolan, J. P., Bossaert, L. L., Greif, R., Maconochie, I. K., Nikolaou, N. I., Perkins, G. D., Soar, J., Truhlář, A., Wyllie, J., et al. (2015) · Resuscitation · doi:10.1016/j.resuscitation.2015.07.038 · Cited by 915
Colloids versus crystalloids for fluid resuscitation in critically ill people
Lewis, S. R., Pritchard, M. W., Evans, D. J., Butler, A. R., Alderson, P., Smith, A. F., & Roberts, I. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000567.pub7 · Cited by 315
Moeller, C., Fleischmann, C., Thomas-Rueddel, D., Vlasakov, V., Rochwerg, B., Theurer, P., Gattinoni, L., Reinhart, K., & Hartog, C. S. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.04.011 · Cited by 159
Kleinman, M. E., de Caen, A. R., Chameides, L., Atkins, D. L., Berg, R. A., Berg, M. D., Bhanji, F., Biarent, D., Bingham, R., Coovadia, A. H., et al. (2010) · Pediatrics · doi:10.1542/peds.2010-2972a · Cited by 86
Metadata
- Authors
- Dung, N. M., Day, N. P. J., Tam, D. T. H., Loan, H. T., Chau, H. T. T., Minh, L. N., Diet, T. V., Bethell, D. B., Kneen, R., Hien, T. T., White, N. J., & Farrar, J. J.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-10
- Volume
- 29
- Issue
- 4
- Pages
- 787-794
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2050003410
- Cited by
- 233
- References
- 0
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Fluid Replacement in Dengue Shock Syndrome: A Randomized, Double‐Blind Comparison of Four Intravenous‐Fluid Regimens. https://app.cochat.ai/papers/10.1086/520435
- The paper
- Dung, N. M., Day, N. P. J., Tam, D. T. H., Loan, H. T., Chau, H. T. T., Minh, L. N., Diet, T. V., Bethell, D. B., Kneen, R., Hien, T. T., White, N. J., & Farrar, J. J. (1999). Fluid Replacement in Dengue Shock Syndrome: A Randomized, Double‐Blind Comparison of Four Intravenous‐Fluid Regimens. Clinical Infectious Diseases. https://doi.org/10.1086/520435
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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