The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Fatal Outbreak of Human Toxoplasmosis along the Maroni River: Epidemiological, Clinical, and Parasitological Aspects
Abstract
BACKGROUND: Well-documented outbreaks of human toxoplasmosis infection are infrequently reported. Here, we describe a community outbreak of multivisceral toxoplasmosis that occurred in Patam, a Surinamese village near the French Guianan border. METHODS: From the end of December 2003 through the middle of January 2004, 5 adult patients in Patam, including 2 pregnant women, were initially hospitalized for multivisceral toxoplasmosis. A French-Surinamese epidemiological investigation was conducted in the village; inquiries and clinical examinations were performed, and blood and environmental samples were obtained. For all serologically confirmed cases of toxoplasmosis, molecular analysis and mouse inoculations were performed for diagnosis and genetic characterization of Toxoplasma gondii. RESULTS: The hospitalized patients, who did not have any immunodeficiencies, presented with an infectious disease with multivisceral involvement. Serological examination confirmed acute toxoplasmosis. One adult died, and a neonate and a fetus with congenital toxoplasmosis also died. During the investigation, 4 additional acute cases of toxoplasmosis were diagnosed among the 33 villagers. Only 3 inhabitants had serological evidence of previous T. gondii infection. In total, we reported 11 cases of toxoplasmosis: 8 multivisceral cases in immunocompetent adults, resulting in 1 death; 2 cases of lethal congenital toxoplasmosis in a neonate and a fetus; and 1 symptomatic case in a child. Molecular analysis demonstrated that identical isolates of only 1 atypical strain were responsible for at least 5 of the 11 cases of toxoplasmosis in the outbreak. No epidemiological sources could be linked to this severe community-wide outbreak of toxoplasmosis. CONCLUSION: This report is in agreement with the particular features of toxoplasmosis involving atypical strains that were recently described in French Guiana.
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Cites
Toxoplasma gondii: transmission, diagnosis and prevention
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Genetic diversity, clonality and sexuality in Toxoplasma gondii
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Self-citationWaterborne Toxoplasmosis, Brazil, from Field to Gene
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Self-citationOocyst-Transmitted Toxoplasmosis Associated with Ingestion of Contaminated Water
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Foodborne Outbreaks of Human Toxoplasmosis
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TOXOPLASMOSIS INFECTION ASSOCIATED WITH EATING UNDERCOOKED VENISON
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Cited by
Acinetobacter baumannii : Emergence of a Successful Pathogen
Peleg, A. Y., Seifert, H., & Paterson, D. L. (2008) · Clinical Microbiology Reviews · doi:10.1128/cmr.00058-07 · Cited by 3,316
Resistance Plasmid Families in Enterobacteriaceae
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Waterborne transmission of protozoan parasites: Review of worldwide outbreaks – An update 2004–2010
Baldursson, S., & Karanis, P. (2011) · Water Research · doi:10.1016/j.watres.2011.10.013 · Cited by 789
Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice
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Elbez‐Rubinstein, A., Ajzenberg, D., Dardé, M., Cohen, R., Dumètre, A., Yera, H., Gondon, E., Janaud, J., & Thulliez, P. (2009) · The Journal of Infectious Diseases · doi:10.1086/595793 · Cited by 318
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Metadata
- Authors
- Demar, M., Ajzenberg, D., Maubon, D., Djossou, F., Panchoe, D., Punwasi, W., Valery, N., Peneau, C., Daigre, J.-L., Aznar, C., Cottrelle, B., Terzan, L., Darde, M.-L., & Carme, B.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-10-01
- Volume
- 45
- Issue
- 7
- Pages
- e88-e95
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2003506359
- Cited by
- 338
- References
- 13
- FWCI
- 15.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Demar, M., Ajzenberg, D., Maubon, D., Djossou, F., Panchoe, D., Punwasi, W., Valery, N., Peneau, C., Daigre, J.-L., Aznar, C., Cottrelle, B., Terzan, L., Darde, M.-L., & Carme, B. (2007). Fatal Outbreak of Human Toxoplasmosis along the Maroni River: Epidemiological, Clinical, and Parasitological Aspects. Clinical Infectious Diseases. https://doi.org/10.1086/521246
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