VAR2CSA Expression on the Surface of Placenta‐Derived Plasmodium falciparum–Infected Erythrocytes
Abstract
Malaria remains a major threat, in sub-Saharan Africa primarily, and the most deadly infections are those with Plasmodium falciparum. Pregnancy-associated malaria is a clinically important complication of infection; it results from a unique interaction between proteoglycans in the placental intervillous space and parasite antigens. Both placental and chondroitin sulphate A-selected parasites have high-level transcripts of a unique var gene named var2csa. However, VAR2CSA has not been consistently found by proteomic analysis of placental parasites. Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA.
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Antibodies raised against DBL3x and DBL5ε are highly cross-reactive with heterologous parasites.
“a recent study illustrated how antibodies raised against DBL3x and DBL5ε were highly cross-reactive with heterologous parasites [42].”
From Differential recognition of P. falciparum VAR2CSA domains by naturally acquired antibodies in pregnant women from a malaria endemic area (2010) · cites this paper as [42]
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References 15 · Cited by 61
- Authors
- Magistrado, P., Salanti, A., Tuikue Ndam, N. G., Mwakalinga, S. B., Resende, M., Dahlbäck, M., Hviid, L., Lusingu, J., Theander, T. G., & Nielsen, M. A.
- Affiliations
- University of Copenhagen (DK)
- National Institute for Medical Research (TZ)
- Corresponding author
- Nielsen, Morten A.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10
- Volume
- 198
- Issue
- 7
- Pages
- 1071-1074
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2131386886
- Cited by
- 61
- References
- 15
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- VAR2CSA, Plasmodium falciparum, malaria in pregnancy, placenta, infected erythrocytes, parasite surface antigens, chondroitin sulfate A, proteoglycans, cross-reactive antibodies
- MeSH terms
- Animals, Antigens, Protozoan, Erythrocytes, Female, Humans, Placenta, Pregnancy
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