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Cited by 657

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Risk of Sequelae after Chlamydia trachomatis Genital Infection in Women

Open access
Haggerty, Catherine L., Gottlieb, Sami L., Taylor, Brandie D., Low, Nicola, Xu, Fujie, Ness, Roberta B.·2010·The Journal of Infectious Diseases
DOI 10.1086/652395
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Abstract

Chlamydia trachomatis infection, the most common reportable disease in the United States, can lead to pelvic inflammatory disease (PID), infertility, ectopic pregnancy, and chronic pelvic pain. Although C. trachomatis is identified among many women who receive a diagnosis of PID, the incidence and timing of PID and long-term sequelae from an untreated chlamydial infection have not been fully determined. This article examines evidence reviewed as part of the Centers for Disease Control and Prevention Chlamydia Immunology and Control Expert Advisory Meeting; 24 reports were included. We found no prospective studies directly assessing risk of long-term reproductive sequelae, such as infertility, after untreated C. trachomatis infection. Several studies assessed PID diagnosis after untreated chlamydial infection, but rates varied widely, making it difficult to determine an overall estimate. In high-risk settings, 2%-5% of untreated women developed PID within the approximately 2-week period between testing positive for C. trachomatis and returning for treatment. However, the rate of PID progression in the general, asymptomatic population followed up for longer periods appeared to be low. According to the largest studies, after symptomatic PID of any cause has occurred, up to 18% of women may develop infertility. In several studies, repeated chlamydial infection was associated with PID and other reproductive sequelae, although it was difficult to determine whether the risk per infection increased with each recurrent episode. The present review critically evaluates this body of literature and suggests future research directions. Specifically, prospective studies assessing rates of symptomatic PID, subclinical tubal damage, and long-term reproductive sequelae after C. trachomatis infection; better tools to measure PID and tubal damage; and studies on the natural history of repeated chlamydial infections are needed.

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Metadata

Authors
Haggerty, C. L., Gottlieb, S. L., Taylor, B. D., Low, N., Xu, F., & Ness, R. B.
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2010-06-15
Volume
201
Issue
S2
Pages
134-155
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1086/652395
OpenAlex
W2116059401
Cited by
657
References
57
FWCI
33.11
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Risk of Sequelae after Chlamydia trachomatis Genital Infection in Women. https://app.cochat.ai/papers/10.1086/652395
The paper
Haggerty, C. L., Gottlieb, S. L., Taylor, B. D., Low, N., Xu, F., & Ness, R. B. (2010). Risk of Sequelae after Chlamydia trachomatis Genital Infection in Women. The Journal of Infectious Diseases. https://doi.org/10.1086/652395

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.