Geoclimatic influences on invasive aspergillosis after hematopoietic stem cell transplantation
Open accessAbstract
BACKGROUND: Aspergillus species are ubiquitous. We hypothesized that climatic variables that affect airborne mold counts affect the incidence of invasive aspergillosis (IA). METHODS: Patients who received hematopoietic stem cell transplants (HSCTs) in geographically and climatically diverse regions (Seattle, WA, and Houston, TX) were examined. Cumulative incidence function, Kaplan-Meier analysis, and Cox proportional hazards regression were performed to examine the association between IA and season. Poisson regression analysis was performed to evaluate the seasonal patterns in IA rates and association with spore counts and climate. RESULTS: In Seattle, the 3-month incidence of IA was 4.6% (5.7% in allograft recipients and 0.8% in autograft recipients). During the 10-year study period, there was a decrease in the incidence of IA among allogeneic HSCT recipients, corresponding to decreased risks during the nonsummer months; receipt of HSCTs during the summer months was associated with an increased hazard for IA (hazard ratio, 1.87; 95% confidence interval, 1.25-2.81) after adjustment for other known risks. The person-month IA rate in Seattle was positively associated with environmental spore counts, which increased with high temperature and low precipitation. No seasonal effect on IA was observed in Houston, where total spore counts were lower and not variable by climate. CONCLUSIONS: Climatic variables differentially affect airborne spore counts and IA risk in geographically disparate centers.
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In a study of invasive aspergillosis from large transplant centers in Seattle and Houston, increased incidence rates of invasive aspergillosis during summer months among hematopoietic stem cell transplant recipients in Seattle than in non-summer months were observed, but this finding was not visible in the Houston center cohort.
“This hypothesis was tested in a study of IA from large transplant centers in Seattle, Washington and Houston, Texas, which showed increased incidence rates of IA during summer months among HSCT in Seattle than in non-summer months. These findings were likely due to the higher burden of Aspergillus spp. spores in the air during the drier warm season following the rainy seasons, but such finding was”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [73]
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References 34 · Cited by 169
Research works printed but not linked: 1
- [29]Aitkin M Anderson D Francis B Hinde J Statistical modeling in GLIM 1989 Clarendon Press Oxford
- Authors
- Panackal, A. A., Li, H., Kontoyiannis, D. P., Mori, M., Perego, C. A., Boeckh, M., & Marr, K. A.
- Affiliations
- Harvard University (US)
- Oregon Health & Science University (US)
- The University of Texas MD Anderson Cancer Center (US)
- Fred Hutch Cancer Center (US)
- Johns Hopkins University (US)
- Corresponding author
- Marr, Kieren A.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-15
- Volume
- 50
- Issue
- 12
- Pages
- 1588-1597
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC3024009
- OpenAlex
- W2138992100
- Cited by
- 169
- References
- 34
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 9 · 2020: 36 · 2019: 12 · 2018: 7 · 2017: 3 · 2016: 8 · 2015: 10 · 2014: 11 · 2013: 8 · 2012: 8
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services (CA-15704)
- Pfizer
- Fred Hutchinson Cancer Research Center
- Astellas Pharma
- National Institutes of Health (RR024140, CA15704)
- Oregon Clinical and Translational Research Institute (UL1RR024140, RR024140)
- Knight Cancer Institute, Oregon Health and Science University (P30-CA069533)
- National Cancer Institute (CA18029, CA 15704+, P30CA015704, P01CA018029, P30CA069533)
- National Institute of Allergy and Infectious Diseases (AI-54736, U01AI054736, AI51468, R01AI051468, K24AI085118)
- National Center for Research Resources (UL1RR024140)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- invasive aspergillosis, hematopoietic stem cell transplantation, climate, seasonal variation, Aspergillus, temperature, precipitation, allogeneic transplantation, autologous transplantation, Seattle, Houston
- MeSH terms
- Adolescent, Adult, Air Microbiology, Aspergillosis, Aspergillus, Environmental Monitoring, Female, Humans, Male, Middle Aged, Seasons, Spores, Texas, Washington, Weather, Hematopoietic Stem Cell Transplantation, Young Adult, Epidemiological Monitoring
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