The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Factors Associated with Mortality in Transplant Patients with Invasive Aspergillosis
Open accessAbstract
BACKGROUND: Invasive aspergillosis (IA) is an important cause of morbidity and mortality in hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients. The purpose of this study was to evaluate factors associated with mortality in transplant patients with IA. METHODS: Transplant patients from 23 US centers were enrolled from March 2001 to October 2005 as part of the Transplant Associated Infection Surveillance Network. IA cases were identified prospectively in this cohort through March 2006, and data were collected. Factors associated with 12-week all-cause mortality were determined by logistic regression analysis and Cox proportional hazards regression. RESULTS: Six-hundred forty-two cases of proven or probable IA were evaluated, of which 317 (49.4%) died by the study endpoint. All-cause mortality was greater in HSCT patients (239 [57.5%] of 415) than in SOT patients (78 [34.4%] of 227; P<.001). Independent poor prognostic factors in HSCT patients were neutropenia, renal insufficiency, hepatic insufficiency, early-onset IA, proven IA, and methylprednisolone use. In contrast, white race was associated with decreased risk of death. Among SOT patients, hepatic insufficiency, malnutrition, and central nervous system disease were poor prognostic indicators, whereas prednisone use was associated with decreased risk of death. Among HSCT or SOT patients who received antifungal therapy, use of an amphotericin B preparation as part of initial therapy was associated with increased risk of death. CONCLUSIONS: There are multiple variables associated with survival in transplant patients with IA. Understanding these prognostic factors may assist in the development of treatment algorithms and clinical trials.
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“The global incidence of invasive aspergillosis was previously reported to be 200,000 cases with an associated mortality ranging from 30–80% [108], recently updated to >300,000 cases [20].”
From Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision (2017) · cites this paper as [108]
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Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis
Herbrecht, R., Denning, D. W., Patterson, T. F., Bennett, J. E., Greene, R. E., Oestmann, J.-W., Kern, W. V., Marr, K. A., Ribaud, P., Lortholary, O., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020191 · Cited by 3,304
Self-citationWalsh, T. J., Anaissie, E. J., Denning, D. W., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Segal, B. H., Steinbach, W. J., Stevens, D. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/525258 · Cited by 2,705
Self-citationAşçıoğlu, S., Rex, J. H., de Pauw, B., Bennett, J. E., Billé, J., Crokaert, F., Denning, D. W., Donnelly, J. P., Edwards, J. E., Erjavec, Z., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/323335 · Cited by 2,315
Self-citationEpidemiology and Outcome of Mould Infections in Hematopoietic Stem Cell Transplant Recipients
Marr, K. A., Carter, R. A., Crippa, F., Wald, A., & Corey, L. (2002) · Clinical Infectious Diseases · doi:10.1086/339202 · Cited by 1,446
Self-citationDiagnosis of Invasive Aspergillosis Using a Galactomannan Assay: A Meta-Analysis
Pfeiffer, C. D., Fine, J. P., & Safdar, N. (2006) · Clinical Infectious Diseases · doi:10.1086/503427 · Cited by 964
(2006) · PubMed · Cited by 906
Walsh, T. J., RAAD, I. I., Patterson, T. F., Chandrasekar, P. H., Donowitz, G. R., Graybill, R. J., Greene, R. E., Hachem, R. Y., Hadley, S., Herbrecht, R., et al. (2006) · Clinical Infectious Diseases · doi:10.1086/508774 · Cited by 749
Self-citationCornely, O. A., Maertens, J. A., Bresnik, M., Ebrahimi, R., Ullmann, A. J., Bouza, E., Heußel, C. P., Lortholary, O., Rieger, C. T., Boehme, A., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/514341 · Cited by 744
Wald, A., Leisenring, W., van Burik, J., & Bowden, R. A. (1997) · The Journal of Infectious Diseases · doi:10.1086/516480 · Cited by 742
Combination Antifungal Therapy for Invasive Aspergillosis
Marr, K. A., Boeckh, M., Carter, R. A., Kim, H. W., & Corey, L. (2004) · Clinical Infectious Diseases · doi:10.1086/423380 · Cited by 607
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Wehbe, S., Hachem, R. Y., Chaftari, A., Melek, A., Pascucci, J. A., Jiang, Y., & RAAD, I. I. (2026) · Journal of Fungi · doi:10.3390/jof12090667
Luo, H., Zhang, Q., Zhang, H., Liu, S., Ye, T., 韩翔, Ge, L., Sun, Y., & Yang, F. (2026) · Microorganisms · doi:10.3390/microorganisms14112432
Metadata
- Authors
- Baddley, J. W., Andes, D. R., Marr, K. A., Kontoyiannis, D. P., Alexander, B. D., Kauffman, C. A., Oster, R. A., Anaissie, E. J., Walsh, T. J., Schuster, M. G., Wingard, J. R., Patterson, T. F., Ito, J. I., Williams, O. D., Chiller, T., & Pappas, P. G.
- Affiliations
- University of Alabama (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- The University of Texas MD Anderson Cancer Center (US)
- Duke University (US)
- University of Michigan (US)
- University of Arkansas at Little Rock (US)
- National Institutes of Health (US)
- University of Pennsylvania (US)
- University of Florida (US)
- The University of Texas at San Antonio Health Science Center (US)
- City Of Hope National Medical Center (US)
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Baddley, John W.
- ORCID
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-06-15
- Volume
- 50
- Issue
- 12
- Pages
- 1559-1567
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC2874071
- OpenAlex
- W2133167433
- Cited by
- 303
- References
- 32
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 13 · 2023: 13 · 2022: 14 · 2021: 13 · 2020: 17 · 2019: 16 · 2018: 10 · 2017: 29 · 2016: 30 · 2015: 29 · 2014: 20 · 2013: 18 · 2012: 30
- FWCI
- 16.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DukeSpace (Duke University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (and K24)
- Centers for Disease Control and Prevention
- National Institute of Allergy and Infectious Diseases (K24AI072522, K23AI064613)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Keywords
- invasive aspergillosis, mortality, hematopoietic stem cell transplantation, solid organ transplantation, prognostic factors, neutropenia, renal failure, liver dysfunction, methylprednisolone, amphotericin B, antifungal therapy, malnutrition, central nervous system disorders, race
- MeSH terms
- Adult, Antifungal Agents, Aspergillosis, Female, Humans, Male, Middle Aged, Postoperative Complications, Risk Factors, Cohort Studies, Organ Transplantation, Hematopoietic Stem Cell Transplantation
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