Comparative Analysis of Virulence and Toxin Expression of Global Community‐Associated Methicillin‐Resistant Staphylococcus aureus Strains
Open accessAbstract
The current pandemic of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) skin infections is caused by several genetically unrelated clones. Here, we analyzed virulence of globally occurring CA-MRSA strains in a rabbit skin infection model. We used rabbits because neutrophils from this animal species have relatively high sensitivity to Panton-Valentine leukocidin (PVL), a toxin epidemiologically correlated with many CA-MRSA infections. Virulence in the rabbit model correlated with in vitro neutrophil lysis and transcript levels of phenol-soluble modulin α and α-toxin, but not PVL genes. Furthermore, abscesses caused by USA300 and its PVL-negative progenitor USA500 were comparatively large and similar in size, suggesting that PVL has played a limited role in the evolution of USA300 virulence in the context of skin infections. Our study indicates a major but not exclusive impact of virulence on the epidemiological success of USA300 and other CA-MRSA strains and emphasizes the importance of core genome-encoded toxins in CA-MRSA skin infections.
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USA300 appears to have enhanced virulence as compared to the traditional hospital-associated MRSA strains.
“which appears to have enhanced virulence as compared to the traditional hospital-associated MRSA strains [26], [27], [28].”
From Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection (2013) · cites this paper as [27]
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References 42 · Cited by 175
- Authors
- Li, M., Cheung, G. Y. C., Hu, J., Wang, D., Joo, H., DeLeo, F. R., & Otto, M.
- Affiliations
- Huashan Hospital (CN)
- National Institutes of Health (US)
- Shanghai Medical College of Fudan University (CN)
- Corresponding author
- Li, Min
- Otto, Michael
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-12-15
- Volume
- 202
- Issue
- 12
- Pages
- 1866-1876
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC3058913
- OpenAlex
- W2082297445
- Cited by
- 175
- References
- 42
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 13 · 2015: 14 · 2014: 21 · 2013: 32 · 2012: 21
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Hallym University
- Huashan Hospital
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (ZIAAI000904)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Keywords
- community-associated methicillin-resistant Staphylococcus aureus, virulence, toxin expression, Panton-Valentine leukocidin, alpha-toxin, USA300, skin infections, abscess formation, neutrophil lysis, virulence evolution
- MeSH terms
- Animals, Bacterial Toxins, Disease Models, Animal, Exotoxins, Female, Hemolysin Proteins, Leukocidins, Neutrophils, Rabbits, Skin, Staphylococcal Skin Infections, Virulence, Gene Expression Regulation, Bacterial, Community-Acquired Infections, Gene Expression Profiling, Virulence Factors, Methicillin-Resistant Staphylococcus aureus
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