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Estimation of optical pathlength through tissue from direct time of flight measurement
Open accessAbstract
Quantitation of near infrared spectroscopic data in a scattering medium such as tissue requires knowledge of the optical pathlength in the medium. This can now be estimated directly from the time of flight of picosecond length light pulses. Monte Carlo modelling of light pulses in tissue has shown that the mean value of the time dispersed light pulse correlates with the pathlength used in quantitative spectroscopic calculations. This result has been verified in a phantom material. Time of flight measurements of pathlength across the rat head give a pathlength of 5.3 +/- 0.3 times the head diameter.
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Cited by
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Huppert, T. J., Diamond, S. G., Franceschini, M. A., & Boas, D. A. (2009) · Applied Optics · doi:10.1364/ao.48.00d280 · Cited by 1,817
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Naseer, N., & Hong, K.-S. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00003 · Cited by 988
Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry
Pogue, B. W., & Patterson, M. S. (2006) · Journal of Biomedical Optics · doi:10.1117/1.2335429 · Cited by 837
Spectroscopy and Imaging with Diffusing Light
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Metadata
- Authors
- Delpy, D. T., Cope, M., Zee, P. V. D., Arridge, S., Wray, S., & Wyatt, J.
- Venue
- Physics in Medicine and Biology
- Publisher
- IOP Publishing
- Published
- 1988-12-01
- Volume
- 33
- Issue
- 12
- Pages
- 1433-1442
- ISSN
- 0031-9155 (ISSN-L)
- 1361-6560
- OpenAlex
- W2137523819
- Cited by
- 2,245
- References
- 0
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Delpy, D. T., Cope, M., Zee, P. V. D., Arridge, S., Wray, S., & Wyatt, J. (1988). Estimation of optical pathlength through tissue from direct time of flight measurement. Physics in Medicine and Biology. https://doi.org/10.1088/0031-9155/33/12/008
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