First in vivo traveling wave magnetic particle imaging of a beating mouse heart
Open accessAbstract
Magnetic particle imaging (MPI) is a non-invasive imaging modality for direct detection of superparamagnetic iron-oxide nanoparticles based on the nonlinear magnetization response of magnetic materials to alternating magnetic fields. This highly sensitive and rapid method allows both a quantitative and a qualitative analysis of the measured signal. Since the first publication of MPI in 2005 several different scanner concepts have been presented and in 2009 the first in vivo imaging results of a beating mouse heart were shown. However, since the field of view (FOV) of the first MPI-scanner only covers a small region several approaches and hardware enhancements were presented to overcome this issue and could increase the FOV on cost of acquisition speed. In 2014 an alternative scanner concept, the traveling wave MPI (TWMPI), was presented, which allows scanning an entire mouse-sized volume at once. In this paper the first in vivo imaging results using the TWMPI system are presented. By optimizing the trajectory the temporal resolution is sufficiently high to resolve the dynamic of a beating mouse heart.
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MPI is suitable for imaging vascular and cardiac perfusion as well as intervention monitoring in cardiac procedures.
“MPI is suitable for imaging vascular and cardiac perfusion as well as intervention monitoring in cardiac procedures [195, 196].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [195]
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References 39 · Cited by 60
Research works printed but not linked: 4
- Biederer S, Knopp T, Sattel T F, Erbe M and Buzug T M 2010 Improved estimation of the magnetic nanoparticle diameter with a magnetic particle spectrometer and combined fields Proc. ISMRM 18 954
- Gleich B, Weizenecker J, Timminger H, Bontus C, Schmale I, Rahmer J, Schmidt J, Kanzenbach J and Borgert J 2010 Fast MPI demonstrator with enlarged field of view Proc. ISMRM 18 218
- Kaul M G, Mummert T, Salamon J, Hofmann M, Ittrich H, Adam G, Knopp T and Jung C 2016 The next step towards interventional MPI: real time 3D MPI-guided treatment of a vessel stenosis using a blood pool agent and MRI road map approach Proc. IWMPI
- Klauer P, Rückert M A, Vogel P, Kullmann W H, Jakob P M and Behr V C 2011 Magnetic particle imaging: linear gradient array for imaging with a traveling wave Proc. ISMRM 19 3783
- Authors
- Vogel, P., Rückert, M. A., Klauer, P., Kullmann, W. H., Jakob, P. M., & Behr, V. C.
- Affiliations
- University of Würzburg (DE)
- Technical University of Applied Sciences Würzburg-Schweinfurt (DE)
- Corresponding author
- Vogel, P
- Venue
- Physics in Medicine & Biology
- Publisher
- IOP Publishing
- Published
- 2016-08-19
- Volume
- 61
- Issue
- 18
- Pages
- 6620-6634
- ISSN
- 0031-9155 (ISSN-L)
- 1361-6560
- OpenAlex
- W2517355056
- Cited by
- 60
- References
- 39
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 11 · 2019: 8 · 2018: 8 · 2017: 7
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Physics in Medicine and Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission (279288)
- Deutsche Forschungsgemeinschaft (BE-5293/1-1)
- Bundesministerium für Bildung und Forschung
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Geomagnetism and Paleomagnetism Studies
- Keywords
- magnetic particle imaging, superparamagnetic iron oxide nanoparticles, in vivo cardiac imaging, field of view, temporal resolution
- MeSH terms
- Animals, Dextrans, Heart, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Magnetics, Mice, Magnetite Nanoparticles
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