The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Mechanism of antibacterial activity of copper nanoparticles
Abstract
In a previous communication, we reported a new method of synthesis of stable metallic copper nanoparticles (Cu-NPs), which had high potency for bacterial cell filamentation and cell killing. The present study deals with the mechanism of filament formation and antibacterial roles of Cu-NPs in E. coli cells. Our results demonstrate that NP-mediated dissipation of cell membrane potential was the probable reason for the formation of cell filaments. On the other hand, Cu-NPs were found to cause multiple toxic effects such as generation of reactive oxygen species, lipid peroxidation, protein oxidation and DNA degradation in E. coli cells. In vitro interaction between plasmid pUC19 DNA and Cu-NPs showed that the degradation of DNA was highly inhibited in the presence of the divalent metal ion chelator EDTA, which indicated a positive role of Cu(2+) ions in the degradation process. Moreover, the fast destabilization, i.e. the reduction in size, of NPs in the presence of EDTA led us to propose that the nascent Cu ions liberated from the NP surface were responsible for higher reactivity of the Cu-NPs than the equivalent amount of its precursor CuCl2; the nascent ions were generated from the oxidation of metallic NPs when they were in the vicinity of agents, namely cells, biomolecules or medium components, to be reduced simultaneously.
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Nanoparticles in the Treatment of Infections Caused by Multidrug-Resistant Organisms
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Nanotechnology: An Untapped Resource for Food Packaging
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Antimicrobial Copper-Based Materials and Coatings: Potential Multifaceted Biomedical Applications
Mitra, D., Kang, E.-T., & Neoh, K. G. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b17815 · Cited by 322
Guan, G., Zhang, L., Zhu, J., Wu, H., Li, W., & Sun, Q. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.123542 · Cited by 283
Smart stimuli-responsive hydrogels for drug delivery in periodontitis treatment
Wang, Y., Li, J., Tang, M., Peng, C., Wang, G., Wang, J., Wang, X., Chang, X., Guo, J., & Gui, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114688 · Cited by 100
Metadata
- Authors
- Chatterjee, A. K., Chakraborty, R., & Basu, T.
- Venue
- Nanotechnology
- Publisher
- IOP Publishing
- Published
- 2014-02-28
- Volume
- 25
- Issue
- 13
- Pages
- 135101
- ISSN
- 0957-4484 (ISSN-L)
- 1361-6528
- OpenAlex
- W2045704669
- Cited by
- 868
- References
- 49
- FWCI
- 16.38
- Type
- journal article
- Language
- en
- Open access
- closed
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