A thermosensitive hydrogel based on biodegradable amphiphilic poly(ethylene glycol)–polycaprolactone–poly(ethylene glycol) block copolymers
Open accessAbstract
A series of low molecular weight poly(ethylene glycol)–polycaprolactone–poly(ethylene glycol) (PEG–PCL–PEG) biodegradable block copolymers were successfully synthesized using isophorone diisocyanate (IPDI) as the coupling agent, and were characterized using 1 H NMR and Fourier transform infrared spectroscopy. The aqueous solutions of the PEG–PCL–PEG copolymers displayed a special thermosensitive gel–sol transition when the concentration was above the corresponding critical gel concentration. Gel–sol phase diagrams were recorded using the test-tube-inversion method; they depended on the hydrophilic/hydrophobic balance in the macromolecular structure, as well as some other factors, including the heating history, volume, and the ageing time of the copolymer aqueous solutions and dissolution temperature of the copolymers. As a result, the gel–sol transition temperature range could be altered, which might be very useful for application in injectable drug delivery systems.
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Triblock copolymers are interesting by their possible formation of physically cross-linked and thermosensitive hydrogels that offer alternative materials of choice in designing DDS.
“Triblock copolymers are also interesting by their possible formation of physically cross-linked and thermosensitive hydrogels that offer alternative materials of choice in designing DDS [162].”
From Recent advances in the synthesis of aliphatic polyesters by ring-opening polymerization☆ (2008) · cites this paper as [162]
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Recent advances in the synthesis of aliphatic polyesters by ring-opening polymerization☆
JEROME, C., & LECOMTE, P. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.02.008 · Cited by 590 · see citing works
- Authors
- Gong, C., Qian, Z., Liu, C., Huang, M., Gu, Y., Wen, Y., Kan, B., Wang, K., Dai, M., Li, X., Gou, M., Tu, M., & Wei, Y.
- Affiliations
- Sichuan University (CN)
- Venue
- Smart Materials and Structures
- Publisher
- IOP Publishing
- Published
- 2007-05-18
- Volume
- 16
- Issue
- 3
- Pages
- 927-933
- ISSN
- 0964-1726 (ISSN-L)
- 1361-665X
- OpenAlex
- W2065032955
- Cited by
- 73
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 1 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 7
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Smart Materials and Structures (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Materials Chemistry › Block Copolymer Self-Assembly
- Keywords
- thermosensitive hydrogel, polyethylene glycol, polycaprolactone, isophorone diisocyanate, gel-sol transition, critical gel concentration, hydrophilic-hydrophobic balance, injectable drug delivery, biodegradable polymers, phase transition temperature
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