Cardio-respiratory interactions and relocation of heartbeats within the respiratory cycle during spontaneous and paced breathing
Open accessAbstract
The capability of respiratory sinus arrhythmia (RSA) to generate privileged locations for the occurrence of R-peaks within the respiratory cycle has been questioned in recent works, challenging the hypothesis that RSA might play a role in improving pulmonary gas exchange. We assessed such a capability submitting healthy humans to spontaneous and paced breathing (SB and PB) protocols, estimating the fraction of beats occurring during inspiration, at low, medium, and high respiratory volumes, and during the first and second half of inspiration and expiration. Then, the same fractions were computed assuming a random uniform distribution of heartbeats, and the differences were compared. The results found are as follows: (1) during PB at 6 rpm, heartbeats redistribute toward inspiration; (2) during SB and PB at 12 rpm, heartbeats tend to cluster when respiratory volume is high; (3) since such redistributions are limited in magnitude, it is possible that its physiological relevance is marginal, for instance, in terms of within-cycle variations in lung perfusion; (4) two groups of subjects with considerably different levels of RSA showed similar redistribution of heartbeats, suggesting that this phenomenon might be an underlying effect of the overall cardio-respiratory interactions, and not directly of RSA.
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Studies in humans breathing at 6 breaths per min have reported a tendency for heartbeats to cluster within the inspiratory phase.
“Studies in humans breathing at 6 breaths per min have also reported a tendency for heartbeats to cluster within the inspiratory phase [45–48].”
From The physiological effects of slow breathing in the healthy human (2017) · cites this paper as [46]
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References 27 · Cited by 14
- Authors
- Lopes, T. C., Beda, A., Granja-Filho, P. C. N., Jandre, F. C., & Giannella-Neto, A.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Corresponding author
- Granja-Filho, P C N
- ORCID
- Venue
- Physiological Measurement
- Publisher
- IOP Publishing
- Published
- 2011-07-20
- Volume
- 32
- Issue
- 9
- Pages
- 1389-1401
- ISSN
- 0967-3334 (ISSN-L)
- 1361-6579
- OpenAlex
- W1964817000
- Semantic Scholar
- e5997a81b8cf900c2bf025a451c1b02db6dbf99e
- Cited by
- 14
- References
- 27
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Physiological Measurement (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Keywords
- respiratory sinus arrhythmia, paced breathing, spontaneous breathing, pulmonary gas exchange, pulmonary blood flow, respiratory volume, heart rate variability
- MeSH terms
- Adolescent, Adult, Female, Heart, Heart Rate, Humans, Male, Respiratory Mechanics, Young Adult
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