Post-traumatic stress disorder: a right temporal lobe syndrome?
Open accessAbstract
In a recent paper (Georgopoulos et al 2010 J. Neural Eng. 7 016011) we reported on the power of the magnetoencephalography (MEG)-based synchronous neural interactions (SNI) test to differentiate post-traumatic stress disorder (PTSD) subjects from healthy control subjects and to classify them with a high degree of accuracy. Here we show that the main differences in cortical communication circuitry between these two groups lie in the miscommunication of temporal and parietal and/or parieto-occipital right hemispheric areas with other brain areas. This lateralized temporal-posterior pattern of miscommunication was very similar but was attenuated in patients with PTSD in remission. These findings are consistent with observations (Penfield 1958 Proc. Natl Acad. Sci. USA 44 51-66, Penfield and Perot 1963 Brain 86 595-696, Gloor 1990 Brain 113 1673-94, Banceaud et al 1994 Brain 117 71-90, Fried 1997 J. Neuropsychiatry Clin. Neurosci. 9 420-8) that electrical stimulation of the temporal cortex in awake human subjects, mostly in the right hemisphere, can elicit the re-enactment and re-living of past experiences. Based on these facts, we attribute our findings to the re-experiencing component of PTSD and hypothesize that it reflects an involuntarily persistent activation of interacting neural networks involved in experiential consolidation.
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MEG studies found hyperconnectivity during threat processing in posterior cingulate and right parietal regions, with increased node strength and clustering in the amygdala and medial prefrontal cortex, suggesting reorganization rather than blanket rigidity.
“MEG studies, for instance, found hyperconnectivity during threat processing in posterior cingulate and right parietal regions, with increased node strength and clustering in the amygdala and medial prefrontal cortex, suggesting reorganization rather than blanket rigidity (Engdahl et al., 2010).”
From The body does not keep the score: trauma, predictive coding, and the restoration of metastability (2026) · cites this paper as Engdahl et al., 2010
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References 37 · Cited by 97
Research works printed but not linked: 1
- Institute of Medicine (U.S.). Subcommittee on Posttraumatic Stress Disorder of the Committee on Gulf War and Health: Physiologic, Psychologic, and Psychosocial Effects of Deployment-Related Stress 2006 Posttraumatic Stress Disorder: Diagnosis and Assessment (Washington, DC: National Academies Press)
- Authors
- Engdahl, B., Leuthold, A. C., Tan, H.-R. M., Lewis, S. M., Winskowski, A. M., Dikel, T. N., & Georgopoulos, A. P.
- Affiliations
- University of Minnesota (US)
- United States Department of Veterans Affairs (US)
- ORCID
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2010-10-28
- Volume
- 7
- Issue
- 6
- Pages
- 066005
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- OpenAlex
- W1987646763
- Cited by
- 97
- References
- 37
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 12 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 5
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- post-traumatic stress disorder, right temporal lobe, hemispheric lateralization, re-experiencing, neural network activation, PTSD remission, magnetoencephalography
- MeSH terms
- Adult, Algorithms, Analysis of Variance, Data Interpretation, Statistical, Electric Stimulation, Female, Fixation, Ocular, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Middle Aged, Neural Pathways, Stress Disorders, Post-Traumatic, Temporal Lobe, Magnetoencephalography, Diagnostic and Statistical Manual of Mental Disorders
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