Decellularised porcine peritoneum as a tendon protector sheet
Abstract
Tissue grafts achieve high levels of compositional and mechanical integrity biomimicry and are often considered as the gold standard in clinical practice. Herein, we assessed the potential of decellularised porcine peritoneum (XenoMEM) as a tendon protector sheet and correlated its properties to a commercially available product (TenoGlide ® ). XenoMEM presented lower cross-linking ratio ( p < 0.05), higher mechanical properties ( p < 0.01), lower coefficient of friction ( p < 0.01) and higher ( p < 0.05) cytocompatibility with human tenocytes than TenoGlide ® . In addition, XenoMEM exhibited lower ( p < 0.05) immune response than TenoGlide ® with macrophages. Collectively, these data support the use of XenoMEM in tendon tissue engineering.
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ECM degradation peptides promote M2-like phenotypes in vitro and in vivo.
“promotion of M2-like phenotypes in vitro [40,44,153] and in vivo [152,154,155].”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [153]
The basement membrane site of porcine peritoneum elicits significantly different responses in the same cell type in vitro compared to the connective tissue side.
“For instance, the basement membrane site of porcine peritoneum has been shown to elicit significantly different responses in the same cell type in vitro when compared to the connective tissue side [152,153]”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [153]
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References 75 · Cited by 11
- Authors
- Capella-Monsonís, H., Kelly, J., Kearns, S., & Zeugolis, D. I.
- Affiliations
- University Hospital Galway (IE)
- Science Foundation Ireland (IE)
- Corresponding author
- Kelly, Jack
- Kearns, Stephen
- Zeugolis, Dimitrios I
- Venue
- Biomedical Materials
- Publisher
- IOP Publishing
- Published
- 2019-06-19
- Volume
- 14
- Issue
- 4
- Pages
- 044102
- ISSN
- 1748-6041 (ISSN-L)
- 1748-605X
- OpenAlex
- W2945175233
- Cited by
- 11
- References
- 75
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 2 · 2020: 4
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomedical Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science Foundation Ireland (13/RC/2073)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- tendon tissue engineering, mechanical properties, friction coefficient, cytocompatibility, tenocytes, macrophage immune response, tissue grafts
- MeSH terms
- Tenocytes, Animals, Collagen, Extracellular Matrix, Fibroblasts, Humans, Inflammation, Macrophages, Peritoneum, Solubility, Stress, Mechanical, Swine, Tendons, Tissue Transplantation, Tissue Engineering, Tissue Scaffolds
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