The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.
The CCR5 and CXCR4 Coreceptors—Central to Understanding the Transmission and Pathogenesis of Human Immunodeficiency Virus Type 1 Infection
Abstract
In this review, we will discuss what is known, what is suspected, and what still remains obscure about the central role played by coreceptor expression and usage in the transmission and pathogenic consequences of human immunodeficiency virus type 1 (HIV-1) infection. An emphasis will be on the HIV-1 phenotypic variants that are defined by their usage of the CCR5 or CXCR4 coreceptors, and how the different cellular tropism of these variants influences how and where HIV-1 replicates in vivo. We will also review what might happen when coreceptor antagonists are used clinically to treat HIV-1 infection.
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Cited by
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
Allers, K., Hütter, G., Hofmann, J., Loddenkemper, C., Rieger, K., Thiel, E., & Schneider, T. (2011) · Blood · doi:10.1182/blood-2010-09-309591 · Cited by 681
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Hultquist, J. F., Schumann, K., Woo, J. M., Manganaro, L., McGregor, M. J., Doudna, J., Simon, V., Krogan, N. J., & Marson, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.080 · Cited by 170
Galloway, N. L. K., Doitsh, G., Monroe, K. M., Yang, Z., Muñoz-Arias, I., Levy, D. N., & Greene, W. C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.011 · Cited by 160
Melby, T., DeSpirito, M., DeMasi, R., Heilek‐Snyder, G., Greenberg, M. L., & Graham, N. (2006) · The Journal of Infectious Diseases · doi:10.1086/504693 · Cited by 112
Metadata
- Authors
- Moore, J. P., Kitchen, S. G., Pugach, P., & Zack, J. A.
- Venue
- AIDS Research and Human Retroviruses
- Publisher
- SAGE Publications
- Published
- 2004-01
- Volume
- 20
- Issue
- 1
- Pages
- 111-126
- ISSN
- 0889-2229 (ISSN-L)
- 1931-8405
- OpenAlex
- W1966261980
- Cited by
- 494
- References
- 174
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The CCR5 and CXCR4 Coreceptors—Central to Understanding the Transmission and Pathogenesis of Human Immunodeficiency Virus Type 1 Infection. https://app.cochat.ai/papers/10.1089/088922204322749567
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- Moore, J. P., Kitchen, S. G., Pugach, P., & Zack, J. A. (2004). The CCR5 and CXCR4 Coreceptors—Central to Understanding the Transmission and Pathogenesis of Human Immunodeficiency Virus Type 1 Infection. AIDS Research and Human Retroviruses. https://doi.org/10.1089/088922204322749567
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