The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Epidemiology and prevention of clinical and subclinical hypothyroidism.
Abstract
Iodine deficiency is the most common cause of hypothyroidism worldwide. In persons living in iodine-replete areas, causes are congenital, spontaneous because of chronic autoimmune disease (atrophic autoimmune thyroiditis or goitrous autoimmune thyroiditis [Hashimoto's thyroiditis]), or iatrogenic because of goitrogens, drugs, or destructive treatment for thyrotoxicosis. Screening for congenital hypothyroidism exists and its use prevents mental retardation. The prevalence of spontaneous hypothyroidism is between 1% and 2% and is more common in older women and 10 times more common in women than in men. A significant proportion of subjects have asymptomatic chronic autoimmune thyroiditis and 8% of women (10% of women over 55 years of age) and 3% of men have subclinical hypothyroidism. Approximately one third of patients with newly diagnosed overt hypothyroidism have received destructive therapy for hyperthyroidism and indefinite surveillance is required. There is not much that can be done to prevent the occurrence of spontaneous autoimmune hypothyroidism, but if identified early, something can be done to prevent progression to overt disease. Controversy exists as to whether healthy adults would benefit from screening for autoimmune thyroid disease because a significant proportion of subjects tested will have evidence of mild thyroid failure. Case finding in women at menopause or visiting a primary care physician with nonspecific symptoms appears justified.
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“The prevalence in North America and Europe ranges from 0.3%to2%, 3-5 but may affect up to 12% of the population, primarily as subclinical hypothyroidism,withhigherprevalenceinareaswith inadequate nutritional iodine levels. 2,6”
From Hypothyroidism: A Review (2025) · cites this paper as [4]
Citations
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DeGroot, L. J., Abalovich, M., Alexander, E. K., Amino, N., Barbour, L. A., Cobin, R. H., Eastman, C. J., Lazarus, J. H., Luton, D., Mandel, S. J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2803 · Cited by 1,885
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Metadata
- Authors
- Vanderpump, M. P. J., & Tunbridge, W. M. G.
- Affiliations
- The Royal Free Hospital (GB)
- John Radcliffe Hospital (GB)
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2002-10
- Volume
- 12
- Issue
- 10
- Pages
- 839-847
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W2130124581
- Cited by
- 347
- References
- 74
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 15 · 2021: 17 · 2020: 16 · 2019: 30 · 2018: 27 · 2017: 12 · 2016: 10 · 2015: 19 · 2014: 19 · 2013: 24 · 2012: 15
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thyroid (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- hypothyroidism, subclinical hypothyroidism, iodine deficiency, autoimmune thyroiditis, Hashimoto's thyroiditis, congenital hypothyroidism screening, prevalence, sex differences, menopause, prevention
- MeSH terms
- Humans, Hypothyroidism, Mass Screening, Severity of Illness Index, Prevalence
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