The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Fibrin Glue Alone and Skeletal Myoblasts in a Fibrin Scaffold Preserve Cardiac Function after Myocardial Infarction
Abstract
Current efforts in cardiac tissue engineering center around the use of scaffolds that deliver cells to the epicardial surface. In this study, we examined the effects of fibrin glue as an injectable scaffold and wall support in ischemic myocardium. The left coronary artery of rats was occluded for 17 min, followed by reperfusion. Echocardiography was performed 8 days after infarction. One to 2 days later, either 0.5% bovine serum albumin (BSA) in phosphate-buffered saline, fibrin glue alone, skeletal myoblasts alone, or skeletal myoblasts in fibrin glue were injected into the ischemic left ventricle. Echocardiography was again performed 5 weeks after injection. The animals were then sacrificed and the hearts were fresh frozen and sectioned for histology and immunohistochemistry. Both the fractional shortening (FS) and infarct wall thickness of the BSA group decreased significantly after 5 weeks (p = 0.0005 and 0.02, respectively). In contrast, both measurements for the fibrin glue group, cells group, and cells in fibrin glue group did not change significantly (FS: p = 0.18, 0.89, and 0.19, respectively; wall thickness: p = 0.40, 0.44, 0.43, respectively). Fibrin glue is capable of preserving infarct wall thickness and cardiac function after a myocardial infarction in rats and may be useful as a biomaterial scaffold for myocardial cell transplantation.
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Cites
Bone marrow cells regenerate infarcted myocardium
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Mechanisms and Models in Heart Failure: A Combinatorial Approach
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Self-citation
Cited by
Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering
Singelyn, J. M., DeQuach, J. A., Seif-Naraghi, S. B., Littlefield, R. B., Schup-Magoffin, P. J., & Christman, K. L. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.06.045 · Cited by 532
Self-citationSingelyn, J. M., Sundaramurthy, P., Johnson, T. D., Schup-Magoffin, P. J., Hu, D. P., Faulk, D. M., Wang, J., Mayle, K. M., Bartels, K., Salvatore, M., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.10.888 · Cited by 372
Self-citationAn overview of injectable polymeric hydrogels for tissue engineering
Sivashanmugam, A., Arun Kumar, R., Vishnu Priya, M., Nair, S. V., & Jayakumar, R. (2015) · European Polymer Journal · doi:10.1016/j.eurpolymj.2015.05.014 · Cited by 366
Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease
Gourdie, R. G., Dimmeler, S., & Kohl, P. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.89 · Cited by 332
Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering
Li, Y., Meng, H., Liu, Y., & Lee, B. P. (2015) · The Scientific World Journal · doi:10.1155/2015/685690 · Cited by 320
Metadata
- Authors
- Christman, K. L., Fok, H. H., Sievers, R. E., Fang, Q., & Lee, R. J.
- Venue
- Tissue Engineering
- Publisher
- SAGE Publications
- Published
- 2004-03
- Volume
- 10
- Issue
- 3-4
- Pages
- 403-409
- ISSN
- 1076-3279 (ISSN-L)
- 1557-8690
- OpenAlex
- W2172722284
- Cited by
- 419
- References
- 35
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Christman, K. L., Fok, H. H., Sievers, R. E., Fang, Q., & Lee, R. J. (2004). Fibrin Glue Alone and Skeletal Myoblasts in a Fibrin Scaffold Preserve Cardiac Function after Myocardial Infarction. Tissue Engineering. https://doi.org/10.1089/107632704323061762
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
