The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
Zinc Finger Proteins as Potential Targets for Toxic Metal Ions: Differential Effects on Structure and Function
Abstract
Zinc finger structures are frequently found in transcription factors and DNA repair proteins, mediating DNA-protein and protein-protein binding. As low concentrations of transition metal compounds, including those of cadmium, nickel, and cobalt, have been shown to interfere with DNA transcription and repair, several studies have been conducted to elucidate potential interactions of toxic metal ions with zinc-binding protein domains. Various effects have been identified, including the displacement of zinc, e.g., by cadmium or cobalt, the formation of mixed complexes, incomplete coordination of toxic metal ions, as well as the oxidation of cysteine residues within the metal-binding domain. Besides the number of cysteine and/or histidine ligands, unique structural features of the respective protein under investigation determine whether or not zinc finger structures are disrupted by one or more transition metals. As improper folding of zinc finger domains is mostly associated with the loss of correct protein function, disruption of zinc finger structures may result in interference with manifold cellular processes involved in gene expression, growth regulation, and maintenance of the genomic integrity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“As induces genotoxicity by generating ROS in similar fashion as cytotoxicity [103].”
From Arsenic Contamination of Groundwater: A Review of Sources, Prevalence, Health Risks, and Strategies for Mitigation (2014) · cites this paper as [103]
Citations
Cites
1 retracted
BRCA1 required for transcription-coupled repair of oxidative DNA damage
Gowen, L. C., Avrutskaya, A. V., Latour, A. M., Koller, B. H., & Leadon, S. A. (1998) · Science · doi:10.1126/science.281.5379.1009 · Cited by 496
RetractedCrystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,559 · cited 1×
“Cys 3 His 1 zinc coordination is also present in the metal-binding domain of the tumor suppressor protein p53; upon activation in response to stress, the zinc finger mediates high affinity for specific DNA sequences (14).”
Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes.
Miller, J., McLachlan, A., & Klug, A. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03825.x · Cited by 2,476
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53
Fang, S., Jensen, J. P., Ludwig, R. L., Vousden, K. H., & Weissman, A. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8945 · Cited by 1,044
ZINC PROTEINS: Enzymes, Storage Proteins, Transcription Factors, and Replication Proteins
Coleman, J. E. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.004341 · Cited by 980
Pelletier, J., Bruening, W., Kashtan, C. E., Mauer, S. M., Manivel, J. C., Striegel, J. E., Houghton, D. C., Junien, C., Habib, R., & Fouser, L. S. (1991) · Cell · doi:10.1016/0092-8674(91)90194-4 · Cited by 948
8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.
Tchou, J. C., Kasai, H., Shibutani, S., Chung, M., Laval, J., Grollman, A. P., & Nishimura, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4690 · Cited by 689
Three-Dimensional Solution Structure of a Single Zinc Finger DNA-Binding Domain
Lee, M. S., Gippert, G. P., Soman, K. V., Case, D. A., & Wright, P. E. (1989) · Science · doi:10.1126/science.2503871 · Cited by 627
Boiteux, S., Gajewski, E., Laval, J., & Dizdaroğlu, M. (1992) · Biochemistry · doi:10.1021/bi00116a016 · Cited by 594
Cadmium, Gene Regulation, and Cellular Signalling in Mammalian Cells
Beyersmann, D., & Hechtenberg, S. (1997) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1997.8125 · Cited by 523
Research works printed but not linked: 3
- Hainaut P, 1993, Cancer Res, 53, 1739
- Sarkar B, 1995, Nutrition, 11, 646
- Sunderman AM, 1988, Ann Clin Lab Sci, 18, 267
Cited by
Sorted by citations
Molecular and cellular mechanisms of cadmium carcinogenesis
Waisberg, M., Joseph, P., Hale, B. A., & Beyersmann, D. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00305-6 · Cited by 1,478
Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms
Beyersmann, D., & Hartwig, A. (2008) · Archives of Toxicology · doi:10.1007/s00204-008-0313-y · Cited by 1,209
Self-citationMechanism and Health Effects of Heavy Metal Toxicity in Humans
Engwa, G. A., Ferdinand, P. U., Nwalo, F. N., & Unachukwu, M. N. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82511 · Cited by 826
Shankar, S., Shanker, U., & Shikha (2014) · The Scientific World Journal · doi:10.1155/2014/304524 · Cited by 616
“As interacts with DNA repair proteins possessing functional zinc finger motifs, which are involved in transcription, DNA repair proteins, and DNA-protein and protein-protein binding [105, 106].”
BackgroundCadmium is a mutagen that acts by inhibiting mismatch repair
Jin, Y. H., Clark, A. B., Slebos, R. J. C., Al-Refai, H., Taylor, J. A., Kunkel, T. A., Resnick, M. A., & Gordenin, D. A. (2003) · Nature Genetics · doi:10.1038/ng1172 · Cited by 473
Metadata
- Authors
- Hartwig, A.
- Affiliations
- Karlsruhe Institute of Technology (DE)
- Corresponding author
- Hartwig, Andrea
- ORCID
- Hartwig, Andrea
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2001-08
- Volume
- 3
- Issue
- 4
- Pages
- 625-634
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W1983045184
- Cited by
- 269
- References
- 63
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 5 · 2023: 12 · 2022: 7 · 2021: 11 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 8 · 2016: 13 · 2015: 15 · 2014: 15 · 2013: 12 · 2012: 14
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antioxidants and Redox Signaling (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Keywords
- zinc finger proteins, toxic metal ions, cadmium, nickel, cobalt, metal ion binding, zinc displacement, heterometallic complexes, cysteine oxidation, histidine ligands, protein misfolding, transcription factors, DNA repair proteins
- MeSH terms
- Binding, Competitive, DNA, DNA Repair, Humans, Metals, Neoplasm Proteins, Protein Binding, Protein Conformation, Structure-Activity Relationship, Transcription Factors, Transcription, Genetic, Xeroderma Pigmentosum, Zinc Fingers, Protein Folding, Denys-Drash Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
