The DOI matches its Crossref record.
Complement Activation and Hemodynamic Changes Following Intravenous Administration of Phosphorothioate Oligonucleotides in the Monkey
Abstract
Rapid intravenous infusion of GEM 91, a 25-mer phosphorothioate oligonucleotide complementary to the gag site of HIV, in the monkey produces transient decreases in peripheral total WBC and neutrophil counts, hemoconcentration, and a brief increase followed by a prolonged decrease in arterial blood pressure. These changes are preceded by and are likely mediated by activation of C5 complement. These effects are dose and infusion rate dependent and can be avoided by administering GEM 91 by slow intravenous infusion. Similar hemodynamic effects are produced with rapid intravenous infusion of other phosphorothioate oligonucleotides varying in length from 20- to 33-mer, and are, therefore, not sequence specific but a property of this chemical structure.
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Citations
Cited by
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Webb, A., Cunningham, D., Cotter, F., Clarke, P., Di Stefano, F., Ross, P., Corbo, M., & Dziewanowska, Z. (1997) · The Lancet · doi:10.1016/s0140-6736(96)11103-x · Cited by 489
Semple, S. C., Klimuk, S. K., Harasym, T. O., Dos Santos, N., Ansell, S. M., Wong, K. F., Maurer, N., Stark, H., Cullis, P. R., Hope, M. J., et al. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00343-6 · Cited by 454
Levin, A. A. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00140-2 · Cited by 438
Metadata
- Authors
- GALBRAITH, W. M., HOBSON, W. C., GICLAS, P. C., SCHECHTER, P. J., & AGRAWAL, S.
- Venue
- Antisense Research and Development
- Publisher
- SAGE Publications
- Published
- 1994-01
- Volume
- 4
- Issue
- 3
- Pages
- 201-206
- ISSN
- 1050-5261 (ISSN-L)
- OpenAlex
- W1240040893
- Cited by
- 238
- References
- 0
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Complement Activation and Hemodynamic Changes Following Intravenous Administration of Phosphorothioate Oligonucleotides in the Monkey. https://app.cochat.ai/papers/10.1089/ard.1994.4.201
- The paper
- GALBRAITH, W. M., HOBSON, W. C., GICLAS, P. C., SCHECHTER, P. J., & AGRAWAL, S. (1994). Complement Activation and Hemodynamic Changes Following Intravenous Administration of Phosphorothioate Oligonucleotides in the Monkey. Antisense Research and Development. https://doi.org/10.1089/ard.1994.4.201
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
