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Bacterial Heme Oxygenases

Frankenberg-Dinkel, Nicole·2004·Antioxidants & Redox Signaling

Abstract

The importance of heme oxygenases in heme catabolism, iron utilization, and cellular signaling has been recognized for many years and is a well studied process in eukaryotes. Through the accessibility of an increasing number of bacterial genomes, it has become evident that heme oxygenases are also widespread in prokaryotes. In these organisms, the heme oxygenase reaction serves a similar function as in eukaryotes. A major role of bacterial heme oxygenases has been attributed to acquisition of iron in prokaryotic pathogens, but other functions, such as involvement in phytobilin biosynthesis, have been described. This review summarizes the current state of the art on bacterial heme oxygenase research. The various biological roles of this enzyme in prokaryotes and their biochemical properties will be discussed.

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Metadata

Authors
Frankenberg-Dinkel, N.
Affiliations
Institute for Microbiology, Technical University Braunschweig, Braunschweig, Germany.
Venue
Antioxidants & Redox Signaling
Published
2004-10
Volume
6
Issue
5
Pages
825-834
ISSN
  • 1523-0864
  • 1557-7716
Cited by
63
References
5
Language
en

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