Mitochondrial Redox Cycling of Mitoquinone Leads to Superoxide Production and Cellular Apoptosis
Cited by (172)
Items 101–172 of 172
- Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cellsTiffany J. Somers‐Edgar, Rhonda J. Rosengren · 2008 · Anti-Cancer Drugs
- Antihypertensive effect of mitochondria-targeted proxyl nitroxidesAnna Dikalova, Igor A. Kirilyuk, Sergey Dikalov · 2014 · Redox Biology
- Mitochondria in Alzheimer’s Disease and Diabetes-Associated Neurodegeneration: License to Heal!Susana Cardoso, Sónia C. Correia, Cristina Carvalho, Paula Isabel Moreira · 2017 · Handbook of experimental pharmacology
- CoQ0-induced mitochondrial PTP opening triggers apoptosis via ROS-mediated VDAC1 upregulation in HL-60 leukemia cells and suppresses tumor growth in athymic nude mice/xenografted nude miceYou‐Cheng Hseu, Varadharajan Thiyagarajan, Ting‐Tsz Ou, Hsin‐Ling Yang · 2017 · Archives of Toxicology
- Mitochondria-Targeted Antioxidants MitoQ and MitoTEMPO Do Not Influence BRAF-Driven Malignant Melanoma and KRAS-Driven Lung Cancer Progression in MiceKristell Le Gal, Clotilde Wiel, Mohamed X. Ibrahim, Marcus Henricsson, Volkan I. Sayin, Martin O. Bergö · 2021 · Antioxidants
- Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in SepsisVera A. Reitsema, Bastiaan S. Star, Vincent D. de Jager, Matijs van Meurs, Robert H. Henning, Hjalmar R. Bouma · 2018 · Antioxidants and Redox Signaling
- Strategies to target bioactive molecules to subcellular compartments. Focus on natural compoundsLucia Biasutto, Andrea Mattarei, Martina La Spina, Michele Azzolini, Sofia Parrasia, Ildikò Szabó, Mario Zoratti · 2019 · European Journal of Medicinal Chemistry
- A Novel Benzoquinone Compound Isolated from Deep-Sea Hydrothermal Vent Triggers Apoptosis of Tumor CellsChenxi Xu, Xumei Sun, Min Jin, Xiaobo Zhang · 2017 · Marine Drugs
- Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied CardiomyocytesVictoriane Peugnet, Maggy Chwastyniak, Paul G.H. Mulder, Steve Lancel, Laurent Bultot, Natacha Fourny, Edith Renguet, Heiko Bugger, Olivia Beseme, Anne Loyens et al. · 2022 · Antioxidants
- Superoxide production by mitochondria of insulin-sensitive tissues: mechanistic differences and effect of early diabetesJudy A. Herlein, Brian D. Fink, William I. Sivitz · 2009 · Metabolism
- A Powerful Mitochondria-Targeted Iron Chelator Affords High Photoprotection against Solar Ultraviolet A RadiationOlivier Reelfs, Vincenzo Abbate, Robert C. Hider, Charareh Pourzand · 2016 · Journal of Investigative Dermatology
- Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cellsHuan Liang, Jody R. Arsenault, Jordan Mortensen, Frank Park, Christopher P. Johnson, Vani Nilakantan · 2009 · APOPTOSIS
- Mitochondrial Targeted Coenzyme Q, Superoxide, and Fuel Selectivity in Endothelial CellsFink, Brian D., O'Malley, Yunxia, Dake, Brian L., Ross, Nicolette C., Prisinzano, Thomas E., Sivitz, William I. · 2009 · PLoS ONE
- Radioprotection by short‐term oxidative preconditioning: Role of manganese superoxide dismutaseNatalia A. Belikova, Ashley L. Glumac, Ruslan Rafikov, Jianfei Jiang, Joel S. Greenberger, Valerian E. Kagan, Hülya Bayır · 2009 · FEBS Letters
- Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative AnalysisCarlos Fernandes, Afonso J. C. Videira, Caroline D. Veloso, Sofia Benfeito, Pedro Soares, João Demétrio Martins, Beatriz Gonçalves, José F. S. Duarte, António M. S. Santos, Paulo Jorge Oliveira et al. · 2021 · Biomolecules
- Mitoquinone does not improve sperm cryo‐resistance in bullsDiogo Ribeiro Câmara, Iulian Ibănescu, Mathias Siuda, H. Bollwein · 2021 · Reproduction in Domestic Animals
- Decylubiquinol impedes mitochondrial respiratory chain complex I activityPaule Bénit, Abdelhamid Slama, Pierre Rustin · 2008 · Molecular and Cellular Biochemistry
- Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation: A negative control for verifying the antioxidant mechanism of MitoQ in cancer and other oxidative pathologiesGang Cheng, Hakim Karoui, Micaël Hardy, Balaraman Kalyanaraman · 2023 · Free Radical Biology and Medicine
- Protection Against Oxidative Stress and “IGF-I Deficiency Conditions”Úrsula Muñoz, Inma Castilla‐Cortázar · 2012 · InTech eBooks
- Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathwaysHongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang · 2019 · Oncology Reports · Retracted
- Activation of TMEM16A by natural product canthaxanthin promotes gastrointestinal contractionQiushuang Ji, Sai Shi, Shuai Guo, Yong Zhan, Hailin Zhang, Yafei Chen, Hailong An · 2020 · The FASEB Journal
- Self-Associating Polymers Chitosan and Hyaluronan for Constructing Composite Membranes as Skin-Wound Dressings Carrying TherapeuticsKatarína Valachová, Ladislav Šoltés · 2021 · Molecules
- Nutraceuticals as a potential adjunct therapy toward improving vascular health in CKDNicholas T. Kruse · 2019 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Effects of NADPH Oxidase Inhibitors and Mitochondria-Targeted Antioxidants on Amyloid β1-42-Induced Neuronal Deaths in Mouse Mixed Cortical CulturesShinae Hwang, Jong-Keun Kim · 2018 · Chonnam Medical Journal
- PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal ratsJoshua R. Sheak, Simin Yan, Laura Weise-Cross, Rosstin Ahmadian, Benjimen R. Walker, Nikki L. Jernigan, Thomas C. Resta · 2020 · American Journal of Physiology-Heart and Circulatory Physiology
- Clinical Applications of AntioxidantsJi-Hoon Park, Gi Ryang Kweon · 2013 · Hanyang Medical Reviews
- MitoQ as a Mitochondria-Targeted Antioxidant in Sperm Cryopreservation: An Updated Review on Its Mechanisms, Efficacy, and Future PerspectivesAbbas Farshad, Axel Wehrend · 2025 · Antioxidants
- Methodology for Use of Mitochondria-Targeted Cations in the Field of Oxidative Stress-Related ResearchM. Yu. Vyssokikh, Yu. N. Antonenko, Konstantin G. Lyamzaev, Tatyana I. Rokitskaya, Vladimir P. Skulachev · 2015 · Methods in molecular biology
- Contributions and Limitations of Mitochondria-Targeted and Non-Targeted Antioxidants in the Treatment of Parkinsonism: an Updated ReviewPriyajit Banerjee, Ishita Saha, Diptendu Sarkar, Arpan Kumar Maiti · 2022 · Neurotoxicity Research
- Changing ROS, NAD and AMP: A path to longevity via mitochondrial therapeuticsOleh V. Lushchak, Dmytro V. Gospodaryov, Olha M. Strilbytska, Maria M. Bayliak · 2023 · Advances in protein chemistry and structural biology
- Protective effect ofMutellina purpureapolyphenolic compounds in doxorubicin-induced toxicity in H9c2 cardiomyocytesSławomir Mańdziuk, Tomasz Baj, Elwira Sieniawska, Jarosław Dudka, Renata Gieroba, Magdalena Iwan, Kazimierz Głowniak · 2014 · Drug and Chemical Toxicology
- Nanoparticle‐based therapeutic strategies for mitochondrial dysfunction in cardiovascular diseaseIsabella Suzuki, Huihua Xing, Joshua Giblin, Anisa Ashraf, Eun Ji Chung · 2024 · Journal of Biomedical Materials Research Part A
- Targeting Hydroxybenzoic Acids to Mitochondria as a Strategy to Delay Skin Ageing: An In Vitro ApproachCarlos Fernandes, Fernando Cagide, Jorge Simões, Carlos Pita, Eurico Pereira, Afonso J. C. Videira, Pedro Soares, José F. S. Duarte, António M. S. Santos, Paulo Jorge Oliveira et al. · 2022 · Molecules
- Mitochondrial Targeted Interventions for AgingSophia Z. Liu, Ying Ann Chiao, Peter S. Rabinovitch, David Joseph Marcinek · 2023 · Cold Spring Harbor Perspectives in Medicine
- Exploring potential targets and mechanisms of PCB52-induced cardiotoxicity: Integration of network toxicology and zebrafish experimental evidenceLinhao Zong, Xiaoyang Lu, Yuxin Yang, Jing Zhao, Ziqi Tang, Dake Cao, Linxia Sun, Miao Guan, Shixia Xu · 2025 · Ecotoxicology and Environmental Safety
- Rational Design of Mitochondria-Targeted Antioxidants: From Molecular Determinants to Clinical PerspectivesBeata Franczyk, Kinga Bojdo, Jakub Chłądzyński, Katarzyna Hossa, Katarzyna Krawiranda, Natalia Krupińska, Natalia Kustosik, Klaudia Leszto, Wiktoria Lisińska, Anna Wieczorek et al. · 2026 · Drugs and Drug Candidates
- Selpercatinib combination with the mitochondria-targeted antioxidant MitoQ effectively suppresses RET–mutant thyroid cancerWenjing Chen, Sophie Y. Dream, Pui-Yin Leung, Pui–Kei Wu, Stuart J. Wong, Jong‐In Park · 2024 · npj Precision Oncology
- Redox Modulation of Mitochondrial Proteins in the Neurotoxicant Models of Parkinson's DiseaseAlika Sarkar, Mohd Sami Ur Rasheed, Mahendra Pratap Singh · 2022 · Antioxidants and Redox Signaling
- Antrodia salmonea‐induced oxidative stress abrogates HER‐2 signaling cascade and enhanced apoptosis in ovarian carcinoma cellsHsin‐Ling Yang, Ruei‐Wan Lin, Peramaiyan Rajendran, Dony Chacko Mathew, Varadharajan Thigarajan, Chuan-Chen Lee, Chih‐Jung Hsu, You‐Cheng Hseu · 2018 · Journal of Cellular Physiology
- SBDS Gene Mutation Increases ROS Production and Causes DNA Damage as Well as Oxidation of Mitochondrial Membranes in the Murine Myeloid Cell Line 32Dcl3Yukihiro Sera, Sakura Yamamoto, Akane Mutou, Shuta Koba, Yuki Kurokawa, Tsuneo Imanaka, Masafumi Yamaguchi · 2024 · Biological and Pharmaceutical Bulletin
- Mitochondria-Targeted AntioxidantsRobin A.J. Smith, Richard C. Hartley, Michael P. Murphy · 2012 · Oxidative stress and disease
- Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survivalPui-Yin Leung, Wenjing Chen, Anissa N Sari, Poojitha Sitaram, Pui–Kei Wu, Susan Tsai, Jong‐In Park · 2024 · World Journal of Gastroenterology
- Programmed cell death as a target to interrupt the aging programFedor F. Severin, Vladimir P. Skulachev · 2011 · Advances in Gerontology
- Review article: Improving mitochondrial function: Current therapeutic perspectives in neurodegenerative diseasesJulia Brechtel, Christine Lietz, Selin Akpinar Adscheid, Kristina Friedland · 2026 · Pharmacological Research
- Effect of mitochondria-targeted antioxidant SkQ1 on aging, lifespan, and spontaneous carcinogenesis in three strains of miceM. N. Yurova, Mark A. Zabezhinski, Tatiana S. Piskunova, Маргарита Леонидовна Тындык, Irina G. Popovich, Vladimir Nikolaevich Anisimov · 2011 · Advances in Gerontology
- Lipid Peroxidation, Diet, and the Genotoxicology of AgingPetr Grúz · 2016 · Elsevier eBooks
- Oxphos targeting of MYCN-amplified neuroblastomaSoraya Epp, Donagh Egan, Evon Poon, Amirah Adlina Abdul Aziz, Kieran J. Wynne, Louis Chesler, Melinda Halász, Walter Kölch · 2025 · Frontiers in Oncology
- How to cancel the program of body aging?Vladimir P. Skulachev · 2010 · Russian Journal of General Chemistry
- Cardiac AgingDao‐Fu Dai, Ying Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, Peter S. Rabinovitch · 2015 · Elsevier eBooks
- Insights into the promising prospect of pharmacological approaches targeting mitochondrial dysfunction in major human diseases: At a glanceMd. Mominur Rahman, Md. Taslim Sarker, Sabbir Ahmed, Md.Nur Uddin, Md. Rezaul Islam, Md. Rezaul Islam, Shanto Das, Nobendu Mukherjee, Hassan A. Hemeg, Abdur Rauf et al. · 2023 · Process Biochemistry
- Antioxidant Action of Mobile Electron Carriers of the Respiratory ChainL ISELI, Tiago Rodrigues, H. Cesar, Juliana C., S. Felipe, K. Mayara, Vivian Moraes · 2012 · InTech eBooks
- The role of mitochondria-targeted antioxidant MitoQ in neurodegenerative diseaseLinlin Zhang, Aurelio Reyes, Xiangdong Wang · 2018 · Journal of Green Engineering
- Concept of Aging as a Result of Slow Programmed Poisoning of an Organism with Mitochondrial Reactive Oxygen SpeciesVladimir P. Skulachev, Alexander V. Bogachev, Felix Osvaldovich Kasparinsky · 2012 · Springer eBooks
- Studies on Mitochondria Directed PlastoquinonesBoris A. Feniouk, Vladimir P. Skulachev · 2018 · Springer eBooks
- Interaction of positively charged ubiquinone analog (MitoQ10) with DT-diaphorase from liver mitochondriaV. I. Kargin, K. A. Motovilov, M. Yu. Vyssokikh, Lev S. Yaguzhinsky · 2008 · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology
- Exploring the therapeutic potential of the mitochondrial transfer-associated enzymatic machinery in brain degenerationNoymar Luque‐Campos, Ricardo Riquelme, Luis Molina, Gisela Canedo-Marroquín, Ana María Vega-Letter, Patricia Luz‐Crawford, Felipe A. Bustamante-Barrientos · 2023 · Frontiers in Physiology
- Quality Characteristics and Antioxidative Activities of Cookies Containing Aruncus dioicus var. kamtschaticus PowderSu-Jung Han, Da Mi Park, Jae‐Joon Lee · 2023 · The Korean Journal of Community Living Science
- Protective effect of mitochondrially targeted antioxidant MitoQ on oxidatively stressed fibroblastsKatarína Valachová, Dominika Topoľská, Ladislav Šoltés · 2017 · Chemical Papers
- Mild mitochondrial uncoupling as potentially effective intervention to slow agingVolodymyr Padalko · 2014 · Oxidants and Antioxidants in Medical Science
- Peroxiredoxin Ⅲ safeguards cardiac function against doxorubicin by regulating mitochondrial quality control via H2O2 detoxificationJi Won Park, Se Yeon Jang, Mi Yeon Kim, Ho Jin Yi, Seong Keun Sonn, Okhee Kweon, Byung‐Hoon Lee, Goo Taeg Oh, Hyun Ae Woo, Tong‐Shin Chang · 2026 · Redox Biology
- New Discoveries Alter the Landscape Potential of Anti-Aging TherapyJoan Smith Sonneborn · 2015 · Journal of Aging Science
- Mitochondrial Therapeutic Approaches in Parkinson’s DiseaseA. Raquel Esteves, Diana Filipa Silva, Maria G-Fernandes, Rui Gomes, Sandra M. Cardoso · 2016 · Springer eBooks
- A New Strategy to Protect the Cell from DamageBoris L. Ikhlov, Andrey V. Melnichenko · 2023 · OALib
- A study of glutathione peroxidase 4 function in human intestinal epithelial cellsPatience Cole Ezea · 2013
- Structural and Metabolic Determinants of Mitochondrial Superoxide and its Detection MethodsAlexander V. Panov, Sergey Dikalov · 2014 · Springer eBooks
- Functional Characterization of a Bidirectional Mammalian Promoter of Two Genes for the Mitochondrial Translational ApparatusErnesto Zanotto · 2009 · Tampere University Institutional Repository (Tampere University)
- Restore mitophagy is essential to prevent cardiac oxidative stress during hypertrophyVictoriane Peugnet, Maggy Chwastyniak, Steve Lancel, Laurent Bultot, Natacha Fourny, Olivia Beseme, Anne Loyens, Wilfried Heyse, Philippe Amouyel, Luc Bertrand et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Modulation of the inflammatory response in hibernation and calorie restrictionVera A. Reitsema · 2021 · University of Groningen research database (University of Groningen / Centre for Information Technology)
- Cardiac agingYing Ann Chiao, Dao‐Fu Dai, Robert J. Wessells, Peter S. Rabinovitch · 2021 · Elsevier eBooks
- Electron Paramagnetic Resonance/Electron Spin ResonanceAbderrezak Khelfi · 2024 · Springer eBooks
- The Impact of Natural and Synthetic Antioxidants in Disease Development in HumansS. Diviya Priya, S. Subhashini, R. Ramesh, L. Anandaraj · 2026 · Springer eBooks
- Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell ProfilingHao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Haitao Zhang · 2026 · Cell Proliferation