Mitochondrial Redox Cycling of Mitoquinone Leads to Superoxide Production and Cellular Apoptosis

Doughan, Abdulrahman K., Dikalov, Sergey I.·2007·Antioxidants & Redox Signaling

Cited by (172)

Items 101–172 of 172

  1. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells
    Tiffany J. Somers‐Edgar, Rhonda J. Rosengren · 2008 · Anti-Cancer Drugs
  2. Antihypertensive effect of mitochondria-targeted proxyl nitroxides
    Anna Dikalova, Igor A. Kirilyuk, Sergey Dikalov · 2014 · Redox Biology
  3. Mitochondria in Alzheimer’s Disease and Diabetes-Associated Neurodegeneration: License to Heal!
    Susana Cardoso, Sónia C. Correia, Cristina Carvalho, Paula Isabel Moreira · 2017 · Handbook of experimental pharmacology
  4. CoQ0-induced mitochondrial PTP opening triggers apoptosis via ROS-mediated VDAC1 upregulation in HL-60 leukemia cells and suppresses tumor growth in athymic nude mice/xenografted nude mice
    You‐Cheng Hseu, Varadharajan Thiyagarajan, Ting‐Tsz Ou, Hsin‐Ling Yang · 2017 · Archives of Toxicology
  5. Mitochondria-Targeted Antioxidants MitoQ and MitoTEMPO Do Not Influence BRAF-Driven Malignant Melanoma and KRAS-Driven Lung Cancer Progression in Mice
    Kristell Le Gal, Clotilde Wiel, Mohamed X. Ibrahim, Marcus Henricsson, Volkan I. Sayin, Martin O. Bergö · 2021 · Antioxidants
  6. Metabolic Resuscitation Strategies to Prevent Organ Dysfunction in Sepsis
    Vera A. Reitsema, Bastiaan S. Star, Vincent D. de Jager, Matijs van Meurs, Robert H. Henning, Hjalmar R. Bouma · 2018 · Antioxidants and Redox Signaling
  7. Strategies to target bioactive molecules to subcellular compartments. Focus on natural compounds
    Lucia Biasutto, Andrea Mattarei, Martina La Spina, Michele Azzolini, Sofia Parrasia, Ildikò Szabó, Mario Zoratti · 2019 · European Journal of Medicinal Chemistry
  8. A Novel Benzoquinone Compound Isolated from Deep-Sea Hydrothermal Vent Triggers Apoptosis of Tumor Cells
    Chenxi Xu, Xumei Sun, Min Jin, Xiaobo Zhang · 2017 · Marine Drugs
  9. Mitochondrial-Targeted Therapies Require Mitophagy to Prevent Oxidative Stress Induced by SOD2 Inactivation in Hypertrophied Cardiomyocytes
    Victoriane Peugnet, Maggy Chwastyniak, Paul G.H. Mulder, Steve Lancel, Laurent Bultot, Natacha Fourny, Edith Renguet, Heiko Bugger, Olivia Beseme, Anne Loyens et al. · 2022 · Antioxidants
  10. Superoxide production by mitochondria of insulin-sensitive tissues: mechanistic differences and effect of early diabetes
    Judy A. Herlein, Brian D. Fink, William I. Sivitz · 2009 · Metabolism
  11. A Powerful Mitochondria-Targeted Iron Chelator Affords High Photoprotection against Solar Ultraviolet A Radiation
    Olivier Reelfs, Vincenzo Abbate, Robert C. Hider, Charareh Pourzand · 2016 · Journal of Investigative Dermatology
  12. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells
    Huan Liang, Jody R. Arsenault, Jordan Mortensen, Frank Park, Christopher P. Johnson, Vani Nilakantan · 2009 · APOPTOSIS
  13. Mitochondrial Targeted Coenzyme Q, Superoxide, and Fuel Selectivity in Endothelial Cells
    Fink, Brian D., O'Malley, Yunxia, Dake, Brian L., Ross, Nicolette C., Prisinzano, Thomas E., Sivitz, William I. · 2009 · PLoS ONE
  14. Radioprotection by short‐term oxidative preconditioning: Role of manganese superoxide dismutase
    Natalia A. Belikova, Ashley L. Glumac, Ruslan Rafikov, Jianfei Jiang, Joel S. Greenberger, Valerian E. Kagan, Hülya Bayır · 2009 · FEBS Letters
  15. Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis
    Carlos Fernandes, Afonso J. C. Videira, Caroline D. Veloso, Sofia Benfeito, Pedro Soares, João Demétrio Martins, Beatriz Gonçalves, José F. S. Duarte, António M. S. Santos, Paulo Jorge Oliveira et al. · 2021 · Biomolecules
  16. Mitoquinone does not improve sperm cryo‐resistance in bulls
    Diogo Ribeiro Câmara, Iulian Ibănescu, Mathias Siuda, H. Bollwein · 2021 · Reproduction in Domestic Animals
  17. Decylubiquinol impedes mitochondrial respiratory chain complex I activity
    Paule Bénit, Abdelhamid Slama, Pierre Rustin · 2008 · Molecular and Cellular Biochemistry
  18. Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation: A negative control for verifying the antioxidant mechanism of MitoQ in cancer and other oxidative pathologies
    Gang Cheng, Hakim Karoui, Micaël Hardy, Balaraman Kalyanaraman · 2023 · Free Radical Biology and Medicine
  19. Protection Against Oxidative Stress and “IGF-I Deficiency Conditions”
    Úrsula Muñoz, Inma Castilla‐Cortázar · 2012 · InTech eBooks
  20. Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathways
    Hongxia Zhang, Ruifeng Dong, Ping Zhang, Yankui Wang · 2019 · Oncology Reports · Retracted
  21. Activation of TMEM16A by natural product canthaxanthin promotes gastrointestinal contraction
    Qiushuang Ji, Sai Shi, Shuai Guo, Yong Zhan, Hailin Zhang, Yafei Chen, Hailong An · 2020 · The FASEB Journal
  22. Self-Associating Polymers Chitosan and Hyaluronan for Constructing Composite Membranes as Skin-Wound Dressings Carrying Therapeutics
    Katarína Valachová, Ladislav Šoltés · 2021 · Molecules
  23. Nutraceuticals as a potential adjunct therapy toward improving vascular health in CKD
    Nicholas T. Kruse · 2019 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  24. Effects of NADPH Oxidase Inhibitors and Mitochondria-Targeted Antioxidants on Amyloid β1-42-Induced Neuronal Deaths in Mouse Mixed Cortical Cultures
    Shinae Hwang, Jong-Keun Kim · 2018 · Chonnam Medical Journal
  25. PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats
    Joshua R. Sheak, Simin Yan, Laura Weise-Cross, Rosstin Ahmadian, Benjimen R. Walker, Nikki L. Jernigan, Thomas C. Resta · 2020 · American Journal of Physiology-Heart and Circulatory Physiology
  26. Clinical Applications of Antioxidants
    Ji-Hoon Park, Gi Ryang Kweon · 2013 · Hanyang Medical Reviews
  27. MitoQ as a Mitochondria-Targeted Antioxidant in Sperm Cryopreservation: An Updated Review on Its Mechanisms, Efficacy, and Future Perspectives
    Abbas Farshad, Axel Wehrend · 2025 · Antioxidants
  28. Methodology for Use of Mitochondria-Targeted Cations in the Field of Oxidative Stress-Related Research
    M. Yu. Vyssokikh, Yu. N. Antonenko, Konstantin G. Lyamzaev, Tatyana I. Rokitskaya, Vladimir P. Skulachev · 2015 · Methods in molecular biology
  29. Contributions and Limitations of Mitochondria-Targeted and Non-Targeted Antioxidants in the Treatment of Parkinsonism: an Updated Review
    Priyajit Banerjee, Ishita Saha, Diptendu Sarkar, Arpan Kumar Maiti · 2022 · Neurotoxicity Research
  30. Changing ROS, NAD and AMP: A path to longevity via mitochondrial therapeutics
    Oleh V. Lushchak, Dmytro V. Gospodaryov, Olha M. Strilbytska, Maria M. Bayliak · 2023 · Advances in protein chemistry and structural biology
  31. Protective effect ofMutellina purpureapolyphenolic compounds in doxorubicin-induced toxicity in H9c2 cardiomyocytes
    Sławomir Mańdziuk, Tomasz Baj, Elwira Sieniawska, Jarosław Dudka, Renata Gieroba, Magdalena Iwan, Kazimierz Głowniak · 2014 · Drug and Chemical Toxicology
  32. Nanoparticle‐based therapeutic strategies for mitochondrial dysfunction in cardiovascular disease
    Isabella Suzuki, Huihua Xing, Joshua Giblin, Anisa Ashraf, Eun Ji Chung · 2024 · Journal of Biomedical Materials Research Part A
  33. Targeting Hydroxybenzoic Acids to Mitochondria as a Strategy to Delay Skin Ageing: An In Vitro Approach
    Carlos Fernandes, Fernando Cagide, Jorge Simões, Carlos Pita, Eurico Pereira, Afonso J. C. Videira, Pedro Soares, José F. S. Duarte, António M. S. Santos, Paulo Jorge Oliveira et al. · 2022 · Molecules
  34. Mitochondrial Targeted Interventions for Aging
    Sophia Z. Liu, Ying Ann Chiao, Peter S. Rabinovitch, David Joseph Marcinek · 2023 · Cold Spring Harbor Perspectives in Medicine
  35. Exploring potential targets and mechanisms of PCB52-induced cardiotoxicity: Integration of network toxicology and zebrafish experimental evidence
    Linhao Zong, Xiaoyang Lu, Yuxin Yang, Jing Zhao, Ziqi Tang, Dake Cao, Linxia Sun, Miao Guan, Shixia Xu · 2025 · Ecotoxicology and Environmental Safety
  36. Rational Design of Mitochondria-Targeted Antioxidants: From Molecular Determinants to Clinical Perspectives
    Beata Franczyk, Kinga Bojdo, Jakub Chłądzyński, Katarzyna Hossa, Katarzyna Krawiranda, Natalia Krupińska, Natalia Kustosik, Klaudia Leszto, Wiktoria Lisińska, Anna Wieczorek et al. · 2026 · Drugs and Drug Candidates
  37. Selpercatinib combination with the mitochondria-targeted antioxidant MitoQ effectively suppresses RET–mutant thyroid cancer
    Wenjing Chen, Sophie Y. Dream, Pui-Yin Leung, Pui–Kei Wu, Stuart J. Wong, Jong‐In Park · 2024 · npj Precision Oncology
  38. Redox Modulation of Mitochondrial Proteins in the Neurotoxicant Models of Parkinson's Disease
    Alika Sarkar, Mohd Sami Ur Rasheed, Mahendra Pratap Singh · 2022 · Antioxidants and Redox Signaling
  39. Antrodia salmonea‐induced oxidative stress abrogates HER‐2 signaling cascade and enhanced apoptosis in ovarian carcinoma cells
    Hsin‐Ling Yang, Ruei‐Wan Lin, Peramaiyan Rajendran, Dony Chacko Mathew, Varadharajan Thigarajan, Chuan-Chen Lee, Chih‐Jung Hsu, You‐Cheng Hseu · 2018 · Journal of Cellular Physiology
  40. SBDS Gene Mutation Increases ROS Production and Causes DNA Damage as Well as Oxidation of Mitochondrial Membranes in the Murine Myeloid Cell Line 32Dcl3
    Yukihiro Sera, Sakura Yamamoto, Akane Mutou, Shuta Koba, Yuki Kurokawa, Tsuneo Imanaka, Masafumi Yamaguchi · 2024 · Biological and Pharmaceutical Bulletin
  41. Mitochondria-Targeted Antioxidants
    Robin A.J. Smith, Richard C. Hartley, Michael P. Murphy · 2012 · Oxidative stress and disease
  42. Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival
    Pui-Yin Leung, Wenjing Chen, Anissa N Sari, Poojitha Sitaram, Pui–Kei Wu, Susan Tsai, Jong‐In Park · 2024 · World Journal of Gastroenterology
  43. Programmed cell death as a target to interrupt the aging program
    Fedor F. Severin, Vladimir P. Skulachev · 2011 · Advances in Gerontology
  44. Review article: Improving mitochondrial function: Current therapeutic perspectives in neurodegenerative diseases
    Julia Brechtel, Christine Lietz, Selin Akpinar Adscheid, Kristina Friedland · 2026 · Pharmacological Research
  45. Effect of mitochondria-targeted antioxidant SkQ1 on aging, lifespan, and spontaneous carcinogenesis in three strains of mice
    M. N. Yurova, Mark A. Zabezhinski, Tatiana S. Piskunova, Маргарита Леонидовна Тындык, Irina G. Popovich, Vladimir Nikolaevich Anisimov · 2011 · Advances in Gerontology
  46. Lipid Peroxidation, Diet, and the Genotoxicology of Aging
    Petr Grúz · 2016 · Elsevier eBooks
  47. Oxphos targeting of MYCN-amplified neuroblastoma
    Soraya Epp, Donagh Egan, Evon Poon, Amirah Adlina Abdul Aziz, Kieran J. Wynne, Louis Chesler, Melinda Halász, Walter Kölch · 2025 · Frontiers in Oncology
  48. How to cancel the program of body aging?
    Vladimir P. Skulachev · 2010 · Russian Journal of General Chemistry
  49. Cardiac Aging
    Dao‐Fu Dai, Ying Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, Peter S. Rabinovitch · 2015 · Elsevier eBooks
  50. Insights into the promising prospect of pharmacological approaches targeting mitochondrial dysfunction in major human diseases: At a glance
    Md. Mominur Rahman, Md. Taslim Sarker, Sabbir Ahmed, Md.Nur Uddin, Md. Rezaul Islam, Md. Rezaul Islam, Shanto Das, Nobendu Mukherjee, Hassan A. Hemeg, Abdur Rauf et al. · 2023 · Process Biochemistry
  51. Antioxidant Action of Mobile Electron Carriers of the Respiratory Chain
    L ISELI, Tiago Rodrigues, H. Cesar, Juliana C., S. Felipe, K. Mayara, Vivian Moraes · 2012 · InTech eBooks
  52. The role of mitochondria-targeted antioxidant MitoQ in neurodegenerative disease
    Linlin Zhang, Aurelio Reyes, Xiangdong Wang · 2018 · Journal of Green Engineering
  53. Concept of Aging as a Result of Slow Programmed Poisoning of an Organism with Mitochondrial Reactive Oxygen Species
    Vladimir P. Skulachev, Alexander V. Bogachev, Felix Osvaldovich Kasparinsky · 2012 · Springer eBooks
  54. Studies on Mitochondria Directed Plastoquinones
    Boris A. Feniouk, Vladimir P. Skulachev · 2018 · Springer eBooks
  55. Interaction of positively charged ubiquinone analog (MitoQ10) with DT-diaphorase from liver mitochondria
    V. I. Kargin, K. A. Motovilov, M. Yu. Vyssokikh, Lev S. Yaguzhinsky · 2008 · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology
  56. Exploring the therapeutic potential of the mitochondrial transfer-associated enzymatic machinery in brain degeneration
    Noymar Luque‐Campos, Ricardo Riquelme, Luis Molina, Gisela Canedo-Marroquín, Ana María Vega-Letter, Patricia Luz‐Crawford, Felipe A. Bustamante-Barrientos · 2023 · Frontiers in Physiology
  57. Quality Characteristics and Antioxidative Activities of Cookies Containing Aruncus dioicus var. kamtschaticus Powder
    Su-Jung Han, Da Mi Park, Jae‐Joon Lee · 2023 · The Korean Journal of Community Living Science
  58. Protective effect of mitochondrially targeted antioxidant MitoQ on oxidatively stressed fibroblasts
    Katarína Valachová, Dominika Topoľská, Ladislav Šoltés · 2017 · Chemical Papers
  59. Mild mitochondrial uncoupling as potentially effective intervention to slow aging
    Volodymyr Padalko · 2014 · Oxidants and Antioxidants in Medical Science
  60. Peroxiredoxin Ⅲ safeguards cardiac function against doxorubicin by regulating mitochondrial quality control via H2O2 detoxification
    Ji Won Park, Se Yeon Jang, Mi Yeon Kim, Ho Jin Yi, Seong Keun Sonn, Okhee Kweon, Byung‐Hoon Lee, Goo Taeg Oh, Hyun Ae Woo, Tong‐Shin Chang · 2026 · Redox Biology
  61. New Discoveries Alter the Landscape Potential of Anti-Aging Therapy
    Joan Smith Sonneborn · 2015 · Journal of Aging Science
  62. Mitochondrial Therapeutic Approaches in Parkinson’s Disease
    A. Raquel Esteves, Diana Filipa Silva, Maria G-Fernandes, Rui Gomes, Sandra M. Cardoso · 2016 · Springer eBooks
  63. A New Strategy to Protect the Cell from Damage
    Boris L. Ikhlov, Andrey V. Melnichenko · 2023 · OALib
  64. A study of glutathione peroxidase 4 function in human intestinal epithelial cells
    Patience Cole Ezea · 2013
  65. Structural and Metabolic Determinants of Mitochondrial Superoxide and its Detection Methods
    Alexander V. Panov, Sergey Dikalov · 2014 · Springer eBooks
  66. Functional Characterization of a Bidirectional Mammalian Promoter of Two Genes for the Mitochondrial Translational Apparatus
    Ernesto Zanotto · 2009 · Tampere University Institutional Repository (Tampere University)
  67. Restore mitophagy is essential to prevent cardiac oxidative stress during hypertrophy
    Victoriane Peugnet, Maggy Chwastyniak, Steve Lancel, Laurent Bultot, Natacha Fourny, Olivia Beseme, Anne Loyens, Wilfried Heyse, Philippe Amouyel, Luc Bertrand et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  68. Modulation of the inflammatory response in hibernation and calorie restriction
    Vera A. Reitsema · 2021 · University of Groningen research database (University of Groningen / Centre for Information Technology)
  69. Cardiac aging
    Ying Ann Chiao, Dao‐Fu Dai, Robert J. Wessells, Peter S. Rabinovitch · 2021 · Elsevier eBooks
  70. Electron Paramagnetic Resonance/Electron Spin Resonance
    Abderrezak Khelfi · 2024 · Springer eBooks
  71. The Impact of Natural and Synthetic Antioxidants in Disease Development in Humans
    S. Diviya Priya, S. Subhashini, R. Ramesh, L. Anandaraj · 2026 · Springer eBooks
  72. Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling
    Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Haitao Zhang · 2026 · Cell Proliferation