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Molecular Mechanism of Proton Translocation by Cytochrome c Oxidase
Abstract
Cytochrome c oxidase (CcO) is a terminal protein of the respiratory chain in eukaryotes and some bacteria. It catalyzes most of the biologic oxygen consumption on earth done by aerobic organisms. During the catalytic reaction, CcO reduces dioxygen to water and uses the energy released in this process to maintain the electrochemical proton gradient by functioning as a redox-linked proton pump. Even though the structures of several terminal oxidases are known, they are not sufficient in themselves to explain the molecular mechanism of proton pumping. Thus, additional extensive studies of CcO by varieties of biophysical and biochemical approaches are involved to shed light on the mechanism of proton translocation. In this review, we summarize the current level of knowledge about CcO, including the latest model developed to explain the CcO proton-pumping mechanism.
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Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
Apel, K., & Hirt, H. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141701 · Cited by 11,723
Mitochondria, oxygen free radicals, disease and ageing
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Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
Semenza, G. L. (2007) · Biochemical Journal · doi:10.1042/bj20070389 · Cited by 541
Radical medicine: treating ageing to cure disease
Finkel, T. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1763 · Cited by 234
Cited by
Theory of Coupled Electron and Proton Transfer Reactions
Hammes-Schiffer, S., & Stuchebrukhov, A. A. (2010) · Chemical Reviews · doi:10.1021/cr1001436 · Cited by 848
Synthetic Fe/Cu Complexes: Toward Understanding Heme-Copper Oxidase Structure and Function
Adam, S. M., Wijeratne, G. B., Rogler, P. J., Diaz, D. E., Quist, D. A., Liu, J. J., & Karlin, K. D. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00074 · Cited by 264
Lenaz, G., & Genova, M. L. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2704 · Cited by 260
Metadata
- Authors
- Belevich, I., & Verkhovsky, M. I.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2008-01
- Volume
- 10
- Issue
- 1
- Pages
- 1-30
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2091807016
- Cited by
- 159
- References
- 4
- FWCI
- 11.97
- Type
- journal article
- Language
- en
- Open access
- closed
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