The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
The Thioredoxin System as a Therapeutic Target in Human Health and Disease
Abstract
The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This system is essential for maintaining the balance of the cellular redox status, and it is involved in the regulation of redox signaling. It is also pivotal for growth promotion, neuroprotection, inflammatory modulation, antiapoptosis, immune function, and atherosclerosis. As an ubiquitous and multifunctional protein, Trx is expressed in all forms of life, executing its function through its antioxidative, protein-reducing, and signal-transducing activities. In this review, the biological properties of the Trx system are highlighted, and its implications in several human diseases are discussed, including cardiovascular diseases, heart failure, stroke, inflammation, metabolic syndrome, neurodegenerative diseases, arthritis, and cancer. The last chapter addresses the emerging therapeutic approaches targeting the Trx system in human diseases. Antioxid. Redox Signal. 19, 1266–1303. I. Oxidative Stress—the Underlying Cause of Many Diseases II. The Trx System A. The Trx-1 gene B. Structure of Trx-1 C. Truncated Trx D. The Trx reductases E. Trx-interacting protein F. Regulation and post-translational modifications of Trx G. Regulation of cell signaling by Trx1 1. Extracellular Trx1 2. Cytoplasmic Trx1 a. Mitogen-activated protein kinases b. Calcium signaling 3. Nuclear Trx1 III. General Functions of Trx A. Role of Trx inapoptosis B. Trx regulates glucocorticoid and ERs IV. The Trx System and Aging V. The Trx System in CVD VI. Physical Exercise and the Trx System VII. The Trx System in the Metabolic Syndrome VIII. The Trx System in Immunity IX. The Trx System and Cancer X. The Trx System in Neurodegenerative Diseases A. Alzheimer's disease B. Parkinson's disease XI. Trx System in RA XII. Trx in Inflammatory Airway Diseases XIII. The Trx System as a Therapeutic Target A. Thioredoxin B. Trx reductase C. Trx-interacting protein XIV. Conclusions
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MiR-23-TrxR1 as a novel molecular axis in skeletal muscle differentiation
Mercatelli, N., Fittipaldi, S., De Paola, E., Dimauro, I., Paronetto, M. P., Jackson, M. J., & Caporossi, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-07575-0 · Cited by 49
Metadata
- Authors
- Mahmood, D. F. D., Abderrazak, A., El Hadri, K., Simmet, T., & Rouis, M.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2013-10-10
- Volume
- 19
- Issue
- 11
- Pages
- 1266-1303
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2003738619
- Cited by
- 305
- References
- 33
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- closed
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