The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Signaling Molecules: Hydrogen Sulfide and Polysulfide
Open accessAbstract
SIGNIFICANCE: Hydrogen sulfide (H2S) has been recognized as a signaling molecule as well as a cytoprotectant. It modulates neurotransmission, regulates vascular tone, and protects various tissues and organs, including neurons, the heart, and kidneys, from oxidative stress and ischemia-reperfusion injury. H2S is produced from l-cysteine by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase. RECENT ADVANCES: In addition to these enzymes, we recently identified a novel pathway to produce H2S from d-cysteine, which involves d-amino acid oxidase (DAO) along with 3MST. These enzymes are localized in the cytoplasm, mitochondria, and peroxisomes. However, some enzymes translocate to organelles under specific conditions. Moreover, H2S-derived potential signaling molecules such as polysulfides and HSNO have been identified. CRITICAL ISSUES: The physiological stimulations, which trigger the production of H2S and its derivatives and maintain their local levels, remain unclear. FUTURE DIRECTIONS: Understanding the regulation of the H2S production and H2S-derived signaling molecules and the specific stimuli that induce their release will provide new insights into the biology of H2S and therapeutic development in diseases involving these substances.
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Self-citationDithiothreitol, a New Protective Reagent for SH Groups*
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Self-citationH 2 S Signals Through Protein S-Sulfhydration
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Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
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Szabo, C., & Papapetropoulos, A. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014050 · Cited by 423
Cysteine Metabolism in Neuronal Redox Homeostasis
Paul, B. D., Sbodio, J. I., & Snyder, S. H. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.02.007 · Cited by 356
Dóka, É., Pader, I., Bíró, A., Johansson, K., Cheng, Q., Ballagó, K., Prigge, J. R., Pastor-Flores, D., Dick, T. P., Schmidt, E. E., et al. (2016) · Science Advances · doi:10.1126/sciadv.1500968 · Cited by 326
Metadata
- Authors
- Kimura, H.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2015-02-10
- Volume
- 22
- Issue
- 5
- Pages
- 362-376
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2319680793
- Cited by
- 351
- References
- 96
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- green
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