A Pilot Study of Stimulant Medication for Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) Who Are Parents of Adolescents with ADHD: The Acute Effects of Stimulant Medication on Observed Parent–Adolescent Interactions
Open accessAbstract
OBJECTIVE: This study explores the use of stimulant medication for parents with attention-deficit/hyperactivity disorder (ADHD) who also have adolescents with ADHD. METHODS: Five parents, diagnosed with ADHD, had their dose of lisdexamfetamine (LDX) titrated to optimal effect. Next, parents and their adolescents completed two interactions, once when parents were on placebo and once when parents were on optimal dose of LDX, to assess acute effects of parental medication on parenting during a neutral discussion (NeuDiss), a problem discussion (ProbDiss), and a homework task (HW). RESULTS: Parents demonstrated a significant decrease in the ratio of commands to total verbalizations during the NeuDiss on LDX compared with placebo. Although no other statistically significant effects emerged at the p<0.05 level, moderate to large effects of medication on some aspects of parenting related to the amount and timing of speech (i.e., total verbalizations, total commands, ratio of commands to total verbalizations, and responsiveness) emerged and varied by task. Parental stimulant medication did not appear to impact the content of parents' speech (i.e., use of negative talk or praise). CONCLUSIONS: These results add to a growing literature suggesting that treatment for parental ADHD may impact parenting performance, and suggest that attention to parental ADHD in treatment for adolescents with ADHD may possibly enhance family functioning.
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In another post hoc analysis of the AWE study, mean BADDS total score decreased from 74.3 at baseline to 40.9 at dose-optimization week 4 for all LDX doses (P < .0001), and optimal response was observed in 67% based on BADDS at week 4.
“Likewise, another post hoc analysis of the AWE study noted the mean BADDS total score from baseline to dose-optimization week 4 decreased from 74.3 to 40.9 for all LDX doses (P < .0001), and the optimal response was observed in 67% of the patients based on BADDS scores at week 4.”
From Review of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder (2017) · cites this paper as [42]
The Methods describe a three-week LDX trial in eight parents of adolescents, with ADHD-RS and CGI assessments; the Results report observed parent–adolescent interactions. Searches for BADDS scores and the AWE week-4 analysis found no passage reporting the claimed scores, P value, or 67% response rate. (LLM, conf=0.78)
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Cites
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“Assessments were completed 2–10 hours post dosing, when LDX has been demonstrated to be efficacious (Wigal et al. 2010).”
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Review of Lisdexamfetamine Dimesylate in Adults With Attention-Deficit/Hyperactivity Disorder
Najib, J., Wimer, D., Zeng, J., Lam, K. W., Romanyak, N., Paige Morgan, E., & Thadavila, A. (2017) · Journal of Central Nervous System Disease · doi:10.1177/1179573517728090 · Cited by 17 · see citing works
- Authors
- Babinski, D. E., Waxmonsky, J. G., Waschbusch, D. A., Humphrey, H., Alfonso, A., Crum, K. I., Bernstein, M., Slavec, J., Augustus, J. N., & Pelham, W. E.
- Affiliations
- Florida International University (US)
- Corresponding author
- Babinski, Dara E.
- Venue
- Journal of Child and Adolescent Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2014-12
- Volume
- 24
- Issue
- 10
- Pages
- 582-585
- ISSN
- 1044-5463 (ISSN-L)
- 1557-8992
- PMC
- PMC4268552
- OpenAlex
- W1458465024
- Cited by
- 7
- References
- 2
- Citations by year
- 2020: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Child and Adolescent Psychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shire
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- parental ADHD, stimulant medication, lisdexamfetamine, parenting, parent-adolescent interaction, family functioning, parental responsiveness
- MeSH terms
- Lisdexamfetamine Dimesylate, Adolescent, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Dextroamphetamine, Female, Humans, Male, Middle Aged, Parent-Child Relations, Pilot Projects, Parenting
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