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Cited by 611

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The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

NEBERT, DANIEL W., NELSON, DAVID R., ADESNIK, MILTON, COON, MINOR J., ESTABROOK, RONALD W., GONZALEZ, FRANK J., GUENGERICH, F. PETER, GUNSALUS, IRWIN C., JOHNSON, ERIC F., KEMPER, BYRON, LEVIN, WAYNE, PHILLIPS, IAN R., SATO, RYO, WATERMAN, MICHAEL R.·1989·DNA

Abstract

In this update we provide a list of the 71 P450 genes and the four P450 pseudogenes that have been characterized as of September 30, 1988. The chromosomal locations of many of these genes are also summarized. A modest revision of the initially proposed nomenclature of the P450 superfamily (Nebert et al., DNA 6, 1-11, 1987) is described specifically for the human and mouse chromosomal loci. The motivation for this revision is to conform to the rules of nomenclature for human and mouse genes. Recommendations for the naming of chromosomal loci include the root symbol "CYP" for human ("Cyp" for mouse), denoting "cytochrome P450." We recommend that this root also be used for other organisms. For a chromosomal locus, the root symbol is followed by an Arabic numeral designating the P450 family, a letter indicating the subfamily, and an Arabic numeral representing the individual gene within the family or subfamily. Numbers of the individual genes usually will be assigned in the order the genes are identified. This system is consistent with our earlier proposed nomenclature for P450 families and gene products from all eukaryotes and prokaryotes.

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Metadata

Authors
NEBERT, D. W., NELSON, D. R., ADESNIK, M., COON, M. J., ESTABROOK, R. W., GONZALEZ, F. J., GUENGERICH, F. P., GUNSALUS, I. C., JOHNSON, E. F., KEMPER, B., LEVIN, W., PHILLIPS, I. R., SATO, R., & WATERMAN, M. R.
Venue
DNA
Published
1989-01
Volume
8
Issue
1
Pages
1-13
ISSN
0198-0238 (ISSN-L)
OpenAlex
W2075200935
Cited by
611
References
10
FWCI
154.57
Type
journal article
Language
en
Open access
closed

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NEBERT, D. W., NELSON, D. R., ADESNIK, M., COON, M. J., ESTABROOK, R. W., GONZALEZ, F. J., GUENGERICH, F. P., GUNSALUS, I. C., JOHNSON, E. F., KEMPER, B., LEVIN, W., PHILLIPS, I. R., SATO, R., & WATERMAN, M. R. (1989). The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci. DNA. https://doi.org/10.1089/dna.1.1989.8.1

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