Cited by 124TGF-β signaling in diseasesConnective Tissue Growth Factor ResearchSignaling Pathways in Disease

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Identification of a Gene Family Regulated by Transforming Growth Factor-β

Brunner, A., Chinn, J., Neubauer, M., Purchio, A.F.·1991·DNA and Cell Biology

DOI 10.1089/dna.1991.10.293

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Abstract

We have identified two related genes whose mRNAs are increased after treatment with transforming growth factor-β (TGF-β1). Mouse AKR-2B cells were treated with TGF-β1 in the presence of cyclohexamide and a cDNA library was subjected to differential screening. Several TGF-β-induced genes (βIG) were isolated and two of these, βIG-M1 and βIG-M2, were characterized. βIG-M1 and βIG-M2 RNAs were significantly increased after TGF-β1 treatment and both were superinduced in the presence of cyclohexamide. cDNA sequence analysis of βIG-M1 showed that it encoded a 379-amino-acid protein which was 81% homologous to CEF-10, a v- src and TPA-inducible gene, and identical to cyr61, a gene induced by serum in growth-arrested BALB-3T3 cells. cDNA sequence analysis of βIG-M2 showed that it encoded a 348-amino-acid protein that was 50% homologous to βIG-M1. Thirty-eight cysteine residues are conserved between βIG-M1 and βIG-M2, which are clustered at the amino and carboxy ends: The middle regions of the two proteins are cysteine free and display the highest degree of nonhomology. Both proteins contain an amino-terminal cysteine-rich motif common to insulin-like growth factor binding proteins and a carboxy-terminal domain with strong homology to a motif found near the carboxy-terminal of the malarial circumsporozoite protein which may be involved in cell adhesion. The regulation of mRNA encoding these proteins by TGF-β1 suggests that they may be involved in mediating some of the pleiotropic effects of this multipotent modulator of cell growth and differentiation.

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Authors: Brunner, A., Chinn, J., Neubauer, M., & Purchio, A. F.
Affiliations: Bristol-Myers Squibb (United States) (US)
ORCID: Brunner, A.
Venue: DNA and Cell Biology
Publisher: SAGE Publications
Published: 1991-05
Volume: 10
Issue: 4
Pages: 293-300
ISSN: 1044-5498 (ISSN-L)
1557-7430
DOI: 10.1089/dna.1991.10.293
OpenAlex: W2069956524
Cited by: 124
References: 54
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
FWCI: 1.19
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: DNA and Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: TGF-β1, CYR61, gene family, mRNA induction, cysteine-rich motif, cell adhesion, cell growth and differentiation
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Cell Line, Cycloheximide, Gene Expression Regulation, Multigene Family, Molecular Sequence Data, RNA, Messenger, Sequence Homology, Nucleic Acid, Transcription, Genetic, Blotting, Southern, Blotting, Northern, Transforming Growth Factor beta, Mice

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Identification of a Gene Family Regulated by Transforming Growth Factor-β

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