The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Molecular Cloning and Identification of a Receptor-Type Protein Tyrosine Phosphatase, IA-2, from Human Insulinoma
Abstract
A novel 3.6-kb cDNA, IA-2, with a 2,937-bp open reading frame was isolated from a human insulinoma subtraction library (ISL-153). The predicted amino acid sequence and in vitro-translated product of IA-2 cDNA revealed a 979-amino-acid protein with a pI value of 7.09 and a molecular mass of 105,847 daltons. The protein sequence is consistent with a signal peptide, an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain contains an unusual cysteine-rich region following the signal peptide. The intracellular cytoplasmic domain of IA-2 possesses highly conserved regions similar to the catalytic domains found in members of the protein tyrosine phosphatase (PTP) family. Northern blot analysis showed that IA-2 mRNA was expressed in five of five freshly isolated human insulinomas, rat and mouse insulinoma cell lines, and enriched normal mouse islets. It also was found in normal human brain, pituitary, pancreas, and brain tumor cell lines, but not in a variety of other normal or tumor tissues. Based on the sequence and expression data, it appears that IA-2 is a new member of the receptor-type PTP family that is expressed in islet and brain tissues.
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 46,426
A simple method for displaying the hydropathic character of a protein
Kyte, J., & Doolittle, R. F. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90515-0 · Cited by 22,843
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222
Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Baekkeskov, S., Aanstoot, H.-J., Christgai, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., & Camilli, P.-D. (1990) · Nature · doi:10.1038/347151a0 · Cited by 1,964
Progressive sequence alignment as a prerequisitetto correct phylogenetic trees
Feng, D.-F., & Doolittle, R. F. (1987) · Journal of Molecular Evolution · doi:10.1007/bf02603120 · Cited by 1,883
cAMP-DEPENDENT PROTEIN KINASE: FRAMEWORK FOR A DIVERSE FAMILY OF REGULATORY ENZYMES
Taylor, S. S., Buechler, J. A., & Yonemoto, W. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.004543 · Cited by 1,144
The detection and classification of membrane-spanning proteins
Klein, P., Kanehisa, M., & DeLisi, C. (1985) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(85)90375-x · Cited by 835
Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion
Tatemoto, K., Efendić, S., Mutt, V., Makk, G., Feistner, G. J., & Barchas, J. D. (1986) · Nature · doi:10.1038/324476a0 · Cited by 681
Dürkop, H., Latza, U., Hummel, M., Eitelbach, F., Seed, B., & Stein, H. (1992) · Cell · doi:10.1016/0092-8674(92)90180-k · Cited by 643
Cited by
Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L. J., Bartlett, R. J., Ricordi, C., Pietropaolo, M., Eisenbarth, G. S., Bennett, S. T., & Patel, D. D. (1997) · Nature Genetics · doi:10.1038/ng0397-293 · Cited by 945
Verge, C. F., Gianani, R., Kawasaki, E., Yu, L., Pietropaolo, M., Chase, H. P., Eisenbarth, G. S., & Jackson, R. A. (1996) · Diabetes · doi:10.2337/diab.45.7.926 · Cited by 827
Laporte, J., Hu, L. J., Kretz, C., Mandel, J.-L., Kioschis, P., Coy, J. F., Klauck, S. M., Poustka, A., & Dahl, N. (1996) · Nature Genetics · doi:10.1038/ng0696-175 · Cited by 639
Autoimmune Destruction of Pancreatic β Cells
Yoon, J.-W., & Jun, H.-S. (2005) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000178767.67857.63 · Cited by 308
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes
Graham, J., Hagopian, W. A., Kockum, I., Li, L. S., Sanjeevi, C. B., Lowe, R. M., Schaefer, J. B., Zarghami, M., Day, H. L., Landin-Olsson, M., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1346 · Cited by 230
Metadata
- Authors
- LAN, M. S., LU, J., GOTO, Y., & NOTKINS, A. L.
- Venue
- DNA and Cell Biology
- Publisher
- SAGE Publications
- Published
- 1994-05
- Volume
- 13
- Issue
- 5
- Pages
- 505-514
- ISSN
- 1044-5498 (ISSN-L)
- 1557-7430
- OpenAlex
- W2073392026
- Cited by
- 320
- References
- 32
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Molecular Cloning and Identification of a Receptor-Type Protein Tyrosine Phosphatase, IA-2, from Human Insulinoma. https://app.cochat.ai/papers/10.1089/dna.1994.13.505
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- LAN, M. S., LU, J., GOTO, Y., & NOTKINS, A. L. (1994). Molecular Cloning and Identification of a Receptor-Type Protein Tyrosine Phosphatase, IA-2, from Human Insulinoma. DNA and Cell Biology. https://doi.org/10.1089/dna.1994.13.505
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