The Hypoxic Placenta
Open accessAbstract
Hypoxia of the placenta is integral to complications of pregnancy, including preeclampsia, intrauterine growth restriction, and small-for-gestational age babies. Hypoxia in the placenta is associated with vascular remodeling, hypertension, metabolic changes, oxidative stress, mitochondrial dysfunction, and endoplasmic reticular stress. Hypoxia induces similar outcomes in other organs such as the lungs, kidney, and gut. Comparing and contrasting the effects of hypoxia on placental functions and functions of lung, kidney, and gut can lead to novel hypotheses and investigations, furthering our understanding of the impact of hypoxia on these diverse yet similar organs. In this review, we compare and contrast hypoxic placental responses to those in the other organ and cell systems.
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Hypoxia affects both the placenta and fetus and is associated with impaired trophoblast invasion, poor villous development, altered vascularity, reduced spiral artery remodelling and low blood flow on both sides of the placenta.
“It affects both the placenta and fetus and is associated with impaired trophoblast invasion, poor villous development, altered vascularity, reduced spiral artery remodelling and low blood flow on both sides of the placenta (387, 543, 600).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [543]
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References 82 · Cited by 45
- Authors
- Tissot van Patot, M. C., Ebensperger, G., Gassmann, M., & Llanos, A. J.
- Affiliations
- Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology (ZIHP), University of Zürich, Zürich, Switzerland.
- Unidad de Fisiología y Fisiopatología Perinatal (UFFP), Programa de Fisiopatología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile.
- Universidad Peruana Cayetano Heredia (PE)
- University of Chile (CL)
- Venue
- High Altitude Medicine & Biology
- Publisher
- SAGE Publications
- Published
- 2012-09
- Volume
- 13
- Issue
- 3
- Pages
- 176-184
- ISSN
- 1527-0297 (ISSN-L)
- 1557-8682
- OpenAlex
- W2056875618
- Cited by
- 45
- References
- 82
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 3 · 2014: 3 · 2013: 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Locations
- High Altitude Medicine & Biology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- placental hypoxia, preeclampsia, fetal growth restriction, small for gestational age, placental vascular remodeling, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, placental metabolism, lung, kidney, intestine
- MeSH terms
- Adaptation, Physiological, Altitude, Hypoxia, Blood Pressure, Erythropoietin, Female, Humans, Hypertension, Kidney, Lung, Oxygen, Partial Pressure, Placenta, Pregnancy, Pregnancy Complications, Oxidative Stress, Gastrointestinal Tract
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