Outcomes of fertility preservation consults for women at risk for primary ovarian insufficiency due to history of cancer treatment or mosaic Turner syndrome
Abstract
Adolescents and young adults (AYAs) at risk of primary ovarian insufficiency (POI) often request fertility preservation consultation. We report consult/treatment outcomes for 21 cancer survivors and 3 mosaic Turner syndrome (TS) patients (mean age 21.6 at consult, 3 with POI). Ten AYAs (9 survivors, 1 mosaic TS) attempted ovarian stimulation; 4 cancelled for poor response. Of completed cycles, mean 3.8 mature oocytes were retrieved, with mean anti-Müllerian hormone 0.653 ng/mL. Ovarian stimulation for mosaic TS AYA and survivors is possible, even with diminished ovarian reserve. Further study is needed to establish guidelines for patient selection, treatment timing, and stimulation protocols.
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Published data regarding oocyte cryopreservation in individuals with TS entails six retrospective studies and eight case reports comprising a total of 80 individuals ranging in age from 7 to 30 years.
“To date, published data regarding oocyte cryopreservation in individuals with TS entails six retrospective studies and eight case reports comprising a total of 80 individuals ranging in age from 7 to 30 years.578,591,596-607”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [603]
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References 21 · Cited by 4
- Authors
- Ulrich, N. D., Raja, N., Ellman, E., & Moravek, M. B.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Moravek, Molly B.
- Venue
- Journal of Adolescent and Young Adult Oncology
- Publisher
- SAGE Publications
- Published
- 2022-08-01
- Volume
- 11
- Issue
- 4
- Pages
- 427-432
- ISSN
- 2156-5333 (ISSN-L)
- 2156-535X
- OpenAlex
- W3201600827
- Cited by
- 4
- References
- 21
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Adolescent and Young Adult Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- fertility preservation, primary ovarian insufficiency, mosaic Turner syndrome, cancer survivors, adolescents and young adults, ovulation induction, oocyte retrieval, anti-Müllerian hormone, diminished ovarian reserve, chemotherapy-induced ovarian failure
- MeSH terms
- Female, Humans, Neoplasms, Referral and Consultation, Turner Syndrome, Cryopreservation, Primary Ovarian Insufficiency, Fertility Preservation
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