Sleep-Associated Changes in Interleukin-1β mRNA in the Brain
Abstract
Much evidence implicates interleukin-1beta (IL-1beta) in sleep regulation. Two previous studies indicated that levels of IL-1beta in mRNA were affected by sleep. In the current study, levels of IL-1beta mRNA and IL-1 receptor assessory protein (IL-1RAP) mRNA were determined 1 h after the beginning of light and dark periods and after sleep deprivation, using the reverse transcriptase-polymerase chain reaction (RT-PCR) and mutated internal standards. Daytime samples contained relatively more IL-1beta mRNA than nighttime samples, and levels of IL-1beta mRNA were higher after sleep deprivation. These changes occurred in the hypothalamus, hippocampus, cerebral cortex, and mesencephalon/pons. In contrast, the IL-1 RAP mRNA level did not seem to be affected by sleep.
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Increases in brain levels of mRNA of the pro-inflammatory cytokine IL-1b are reported following sleep deprivation by gentle handling, and are higher in daytime than in darkness.
“Specifically, increases in brain levels of mRNA of the pro-inflammatory cytokine IL-1b are reported following sleep deprivation by gentle handling and is reported to be higher in daytime (during the normal sleep period in rodents) than in darkness (during the normal activity time for rodents).59”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [59]
IL-β mRNA levels in brain increase following sleep deprivation by gentle handling and are higher in daytime than in darkness in rodents.
“IL-β messenger ribonucleic acid (mRNA) levels in brain are reported to increase following sleep deprivation by gen tie handling and to be higher in daytime (during the normal sleep period in rodents) than in darkness (during the normal activity time for rodents).22”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [22]
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References 25 · Cited by 88
- Authors
- TAISHI, P., CHEN, Z., OBÁL, F., HANSEN, M. K., ZHANG, J., FANG, J., & KRUEGER, J. M.
- Affiliations
- Washington State University (US)
- University of Szeged (HU)
- University of Tennessee Health Science Center (US)
- Venue
- Journal of Interferon & Cytokine Research
- Publisher
- SAGE Publications
- Published
- 1998-09
- Volume
- 18
- Issue
- 9
- Pages
- 793-798
- ISSN
- 1079-9907 (ISSN-L)
- 1557-7465
- OpenAlex
- W2014598373
- Cited by
- 88
- References
- 25
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 5
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Interferon & Cytokine Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS-27250, NS-31453, NS-25378, R01NS031453, R01NS027250, R01NS025378)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- IL-1β, sleep regulation, sleep deprivation, IL-1 receptor accessory protein, circadian rhythm, hypothalamus, hippocampus, cerebral cortex, brain cytokines
- MeSH terms
- Animals, Brain, Interleukin-1, Male, RNA, Messenger, Sleep, Sleep Deprivation, Signal Transduction, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Rats
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