Combined Effect of Dietary Supplementation with Pressurized Whey and Exercise Training in Chronic Obstructive Pulmonary Disease: A Randomized, Controlled, Double-Blind Pilot Study
Abstract
Pressurized whey supplementation, by its antioxidant and nutritional properties, may improve exercise tolerance and potentiate the effects of exercise training in patients with chronic obstructive pulmonary disease (COPD). In this randomized, double-blind, placebo-controlled study, 22 patients with COPD were allocated to receive active pressurized whey or placebo (casein) dietary supplementation for a 16-week period. Patients continued their usual physical activities for the first 8 weeks, whereas they were subjected to an exercise training program for the remaining 8 weeks of the study. Patients were evaluated at baseline, after 8 weeks of supplementation alone (time point, 8 weeks), and after 8 weeks of its combination with exercise training (time point, 16 weeks). The constant workrate cycle endurance test (CET), potentiated quadriceps twitch force, mid-thigh cross-sectional area, and Chronic Respiratory Questionnaire (CRQ) were used to evaluate the effects of treatments. The inflammatory (C-reactive protein and interleukin-6) and oxidant/antioxidant (protein oxidation and glutathione) blood profiles were also characterized. At week 8, there was no increase in CET time in either group. At week 16, there was a statistically significant increase in CET time in the whey-only group ( P < .05). Further, at week 16, there was clinically significant improvement in the Dyspnea and the Mastery scales of the CRQ in both groups. Also, the Fatigue and Emotional Control scales of the CRQ showed clinically significant improvement in the whey-only group. Study interventions did not modify significantly the systemic inflammatory and oxidative stress markers that were assessed. Thus dietary supplementation with pressurized whey may potentiate the effects of exercise training on exercise tolerance and quality of life in patients with COPD.
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For patients with COPD, results of 2 studies clearly showed benefits from exercise training along with protein supplementation; whey protein served as an effective protein source.
“For patients with COPD, results of 2 studies clearly showed benefits from exercise training along with protein supplementation 162,164 ; whey protein served as an effective protein source.”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [162]
Evidence supports the combination of exercise and protein/amino acid supplementation for prevention and treatment of muscle loss in certain debilitating clinical conditions, including bed rest for acute critical illness or injury and chronic diseases such as COPD and congestive heart failure.
“Evidence supports the combination of exercise and protein/amino acid supplementation for prevention and treatment of muscle loss in certain debilitating clinical conditions, including bed rest for acute critical illness or injury 153e160 and also for chronic diseases, such as COPD 161e165 and congestive heart failure (CHF).99,163,166”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [162]
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Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · see citing works
- Authors
- Laviolette, L., Lands, L. C., Dauletbaev, N., Saey, D., Milot, J., Provencher, S., LeBlanc, P., & Maltais, F.
- Affiliations
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Montreal Children's Hospital (CA)
- Corresponding author
- Maltais, François
- ORCID
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2010-06
- Volume
- 13
- Issue
- 3
- Pages
- 589-598
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W1973780427
- Cited by
- 61
- References
- 3
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 2 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 8
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McGill University
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- chronic obstructive pulmonary disease, whey protein supplementation, exercise training, exercise tolerance, quality of life, dyspnea, fatigue, oxidative stress, inflammation, protein oxidation, glutathione, C-reactive protein, interleukin-6
- MeSH terms
- Whey Proteins, Adult, Aged, C-Reactive Protein, Combined Modality Therapy, Double-Blind Method, Emotions, Exercise Therapy, Female, Humans, Male, Middle Aged, Milk Proteins, Pilot Projects, Quality of Life, Interleukin-6, Exercise Tolerance, Dietary Supplements, Pulmonary Disease, Chronic Obstructive
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