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Cited by 22Blood Pressure and Hypertension StudiesMenopause: Health Impacts and TreatmentsCardiovascular Health and Disease Prevention

The DOI matches its Crossref record; the references it cites are not checked yet.

Cardiovascular Disease in Women: Gender-Specific Aspects of Hypertension and the Consequences of Treatment

LEGATO, MARIANNE J.·1998·Journal of Women's Health
DOI 10.1089/jwh.1998.7.199
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Abstract

The epidemiology, clinical course, response to treatment, and ultimate outcome of essential hypertension vary as a function of gender. Three early trials on hypertension reported an increase in all-cause mortality in treated white women compared with black women or with men of both races. Later studies, however, suggest that drug therapy has similar and beneficial effects in hypertensive men and women. Women may tolerate hypertension better than do men. Diastolic hypertension correlates with higher mortality from coronary artery disease in men than in women. Special considerations apply to treating the hypertensive woman. Use of oral contraceptives may precipitate or accentuate the problem. In contrast, in the postmenopausal female, estrogen replacement may actually improve hypertension, via several mechanisms. These include the impact of the hormone on vasomotricity, its enhancement of baroreceptor sensitivity, and its impact on the hyperinsulinemia characteristic of menopause. Treatment of hypertension must be individualized with respect to gender. More data on the consequences of treatment of women with hypertension are needed, particularly longterm studies to assess the impact of treatment on mortality.

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Metadata

Authors
LEGATO, M. J.
Affiliations
Columbia University Irving Medical Center (US)
Corresponding author
LEGATO, MARIANNE J.
ORCID
LEGATO, MARIANNE J.
Venue
Journal of Women's Health
Publisher
SAGE Publications
Published
1998-03
Volume
7
Issue
2
Pages
199-209
ISSN
1059-7115 (ISSN-L)
DOI
10.1089/jwh.1998.7.199
OpenAlex
W2081408299
Cited by
22
References
50
Citations by year
2019: 1 · 2018: 1 · 2017: 1
FWCI
1.51
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Journal of Women s Health (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
essential hypertension, sex differences, women, antihypertensive therapy, mortality, coronary artery disease, oral contraceptives, estrogen replacement therapy, menopause, hyperinsulinemia, baroreflex sensitivity, vasomotor function, cardiovascular disease in women
MeSH terms
Adult, Aged, Coronary Disease, Female, Hemodynamics, Humans, Hypertension, Male, Menopause, Middle Aged, Pregnancy, Sex Factors, Estrogen Replacement Therapy, Women's Health, Treatment Outcome

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CoChat. (2026). Citation check: Cardiovascular Disease in Women: Gender-Specific Aspects of Hypertension and the Consequences of Treatment. https://app.cochat.ai/papers/10.1089/jwh.1998.7.199
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LEGATO, M. J. (1998). Cardiovascular Disease in Women: Gender-Specific Aspects of Hypertension and the Consequences of Treatment. Journal of Women's Health. https://doi.org/10.1089/jwh.1998.7.199

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.