Coating materials for neural stem/Progenitor cell culture and differentiation
Abstract
Neural stem/progenitor cells (NSPCs) have a potential to treat various neurological diseases, such as Parkinson's Disease, Alzheimer's Disease, and Spinal Cord Injury. However, the limitation of NSPC sources and the difficulty to maintain their stemness or to differentiate them into specific therapeutic cells are the main hurdles for clinical research and application. Thus, for obtaining a therapeutically relevant number of NSPCs in vitro, it is important to understand factors regulating their behaviors and to establish a protocol for stable NSPC proliferation and differentiation. Coating materials for cell culture, such as Matrigel, laminin, collagen, and other coating materials, can significantly affect NSPC characteristics. This article provides a review of coating materials for NSPC culturing in both two dimensions and three dimensions, and their functions in NSPC proliferation and differentiation, and presents a useful guide to select coating materials for researchers.
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Combinatorial approaches (laminin with poly-L-lysine or poly-L-ornithine) enhance cell adhesion through electrostatic interactions and better approximate ECM functionality.
“combinatorial approaches, for example, laminin with poly-L-lysine or poly-L-ornithine, are used to enhance cell adhesion through electrostatic interactions and better approximate ECM functionality (Liu et al., 2020; Hartmann et al., 2023).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Liu et al., 2020
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Spänle, J. V., Haiber, L. M., & Seeger, B. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1800157 · Cited by 1 · see citing works
- Authors
- Liu, D., Pavathuparambil Abdul Manaph, N., Al-Hawwas, M., Bobrovskaya, L., Xiong, L.-L., & Zhou, X.-F.
- Affiliations
- School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
- Neurological Disorders Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
- Venue
- Stem Cells and Development
- Publisher
- SAGE Publications
- Published
- 2020-04-15
- Volume
- 29
- Issue
- 8
- Pages
- 463-474
- ISSN
- 1547-3287
- 1557-8534
- Cited by
- 33
- References
- 0
- Language
- en
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