The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Autologous Mesenchymal Stem Cell-Mediated Repair of Tendon
Abstract
Mesenchymal stem cells (MSCs) were isolated from bone marrow of 18 adult New Zealand White rabbits. These cells were culture expanded, suspended in type I collagen gel, and implanted into a surgically induced defect in the donor s right patellar tendon. A cell-free collagen gel was implanted into an identical control defect in the left patellar tendon. Repair tissues were evaluated biomechanically (n = 13) and histomorphometrically (n = 5) at 4 weeks after surgery. Compared to their matched controls, the MSC-mediated repair tissue demonstrated significant increases of 26% (p < 0.001), 18% (p < 0. 01), and 33% (p < 0.02) in maximum stress, modulus, and strain energy density, respectively. Qualitatively, there appeared to be minor improvements in the histological appearance of some of the MSC- mediated repairs, including increased number of tenocytes and larger and more mature-looking collagen fiber bundles. Morphometrically, however, there were no significant left-right differences in nuclear aspect ratio (shape) or nuclear alignment (orientation). Therefore, delivering a large number of mesenchymal stem cells to a wound site can significantly improve its biomechanical properties by only 4 weeks but produce no visible improvement in its microstructure.
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Cites
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Self-citationNonparametric Statistical Inference
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Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage.
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Self-citationRegulatory Mechanisms in Stem Cell Biology
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Use of mesenchymal stem cells in a collagen matrix for achilles tendon repair
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Self-citationMesenchymal stem cells in bone development, bone repair, and skeletal regenaration therapy
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Bryant, S. J., & Anseth, K. S. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.1217 · Cited by 845
Functional Tissue Engineering: The Role of Biomechanics
Butler, D. L., Goldstein, S. A., & Guilak, F. (2000) · Journal of Biomechanical Engineering · doi:10.1115/1.1318906 · Cited by 624
Self-citationMesenchymal stem cells: paradoxes of passaging
Javazon, E. H., Beggs, K. J., & Flake, A. W. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.02.004 · Cited by 527
Fedorovich, N. E., Alblas, J., de Wijn, J. R., Hennink, W. E., Verbout, A. J., & Dhert, W. J. A. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0175 · Cited by 467
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
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Metadata
- Authors
- Awad, H. A., Butler, D. L., Boivin, G. P., Smith, F. N. L., Malaviya, P., Huibregtse, B., & Caplan, A. I.
- Venue
- Tissue Engineering
- Publisher
- SAGE Publications
- Published
- 1999-06
- Volume
- 5
- Issue
- 3
- Pages
- 267-277
- ISSN
- 1076-3279 (ISSN-L)
- 1557-8690
- OpenAlex
- W2012222854
- Cited by
- 543
- References
- 26
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Awad, H. A., Butler, D. L., Boivin, G. P., Smith, F. N. L., Malaviya, P., Huibregtse, B., & Caplan, A. I. (1999). Autologous Mesenchymal Stem Cell-Mediated Repair of Tendon. Tissue Engineering. https://doi.org/10.1089/ten.1999.5.267
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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