The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Characterization of a Novel Polymeric Scaffold for Potential Application in Tendon/Ligament Tissue Engineering
Abstract
Unlike braided fabrics, knitted scaffolds have been proven to favor deposition of collagenous connective tissue matrix, which is crucial for tendon/ligament reconstruction. But cell seeding of such scaffolds often requires a gel system, which is unstable in a dynamic situation, especially in the knee joint. This study developed a novel, biodegradable nano-microfibrous polymer scaffold by electrospinning PLGA nanofibers onto a knitted PLGA scaffold in order to provide a large biomimetic surface for cell attachment. Porcine bone marrow stromal cells were seeded onto either the novel scaffolds by pipetting a cell suspension (Group I) or the knitted PLGA scaffolds by immobilizing in fibrin gel (Group II). Cell attachment at 36 hours, cell proliferation and extracellular matrix synthesis at 1 week, and mechanical properties over 2 weeks were investigated. Cell attachment was comparable and cell proliferation was faster in Group I. Moreover, cellular function was more actively exhibited in Group I, as evident by the higher expression of collagen I, decorin, and biglycan genes. Thus, this novel scaffold, facilitating cell seeding and promoting cell proliferation, function, and differentiation, could be applied with promise in tissue engineering of tendon/ligament.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
Electrospun nanofibrous structure: A novel scaffold for tissue engineering
Li, W., Laurencin, C. T., Caterson, E. J., Tuan, R. S., & Ko, F. K. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10167 · Cited by 2,427
A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering
Yoshimoto, H., Shin, Y. M., Terai, H., & Vacanti, J. P. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00635-x · Cited by 1,977
Hutmacher, D. W. (2001) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856201744489 · Cited by 1,409
Aligned biodegradable nanofibrous structure: a potential scaffold for blood vessel engineering
Xu, C. Y., Inai, R., Kotaki, M., & Ramakrishna, S. (2004) · Biomaterials · doi:10.1016/s0142-9612(03)00593-3 · Cited by 1,213
Mo, X. M., Xu, C. Y., Kotaki, M., & Ramakrishna, S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.08.042 · Cited by 803
Cell differentiation by mechanical stress
Altman, G. H., Horan, R. L., Martin, I., Farhadi, J., Stark, P. R. H., Volloch, V., Richmond, J. C., Vunjak-Novakovic, G., & Kaplan, D. L. (2002) · The FASEB Journal · doi:10.1096/fj.01-0656fje · Cited by 667
Lee, C. H., Shin, H. J., Cho, I. H., Kang, Y.-M., Kim, I. A., Park, K.-D., & Shin, J.-W. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.04.037 · Cited by 633
Biodegradable Polymer Scaffolds with Well-Defined Interconnected Spherical Pore Network
Ma, P. X., & Choi, J.-W. (2001) · Tissue Engineering · doi:10.1089/107632701300003269 · Cited by 620
Li, W.-J., Tuli, R., Huang, X., Laquerriere, P., & Tuan, R. S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.01.002 · Cited by 616
Cited by
Electrospinning: Applications in drug delivery and tissue engineering
Sill, T. J., & von Recum, H. A. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.01.011 · Cited by 3,289
Xin, X., Hussain, M., & Mao, J. J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.08.042 · Cited by 377
Polymeric Nanofibers in Tissue Engineering
Dahlin, R. L., Kasper, F. K., & Mikos, A. G. (2011) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2011.0238 · Cited by 342
Application of Bone Marrow-Derived Mesenchymal Stem Cells in a Rotator Cuff Repair Model
Gulotta, L. V., Kovacevic, D., Ehteshami, J. R., Dagher, E., Packer, J. D., & Rodeo, S. A. (2009) · The American Journal of Sports Medicine · doi:10.1177/0363546509339582 · Cited by 332
Sahoo, S., Toh, S. L., & Goh, J. C. H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.004 · Cited by 329
Self-citation
Metadata
- Authors
- Sahoo, S., Ouyang, H., Goh, J. C.-H., Tay, T. E., & Toh, S. L.
- Venue
- Tissue Engineering
- Publisher
- SAGE Publications
- Published
- 2006-01
- Volume
- 12
- Issue
- 1
- Pages
- 91-99
- ISSN
- 1076-3279 (ISSN-L)
- 1557-8690
- OpenAlex
- W1988106932
- Cited by
- 332
- References
- 31
- FWCI
- 10.65
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Characterization of a Novel Polymeric Scaffold for Potential Application in Tendon/Ligament Tissue Engineering. https://app.cochat.ai/papers/10.1089/ten.2006.12.91
- The paper
- Sahoo, S., Ouyang, H., Goh, J. C.-H., Tay, T. E., & Toh, S. L. (2006). Characterization of a Novel Polymeric Scaffold for Potential Application in Tendon/Ligament Tissue Engineering. Tissue Engineering. https://doi.org/10.1089/ten.2006.12.91
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
