The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Scaffold Mean Pore Size Influences Mesenchymal Stem Cell Chondrogenic Differentiation and Matrix Deposition
Open accessAbstract
Recent investigations into micro-architecture of scaffolds has revealed that mean pore sizes are cell-type specific and influence cellular shape, differentiation, and extracellular matrix secretion. In this context, the overall goal of this study was to investigate whether scaffold mean pore sizes affect mesenchymal stem cell initial attachment, chondrogenic gene expression, and cartilage-like matrix deposition. Collagen-hyaluronic acid (CHyA) scaffolds, recently developed in our laboratory for in vitro chondrogenesis, were fabricated with three distinct mean pore sizes (94, 130, and 300 μm) by altering the freeze-drying technique used. It was evident that scaffolds with the largest mean pore sizes (300 μm) stimulated significantly higher cell proliferation, chondrogenic gene expression, cartilage-like matrix deposition, and resulting bulk compressive modulus after in vitro culture, relative to scaffolds with smaller mean pore sizes (94, 130 μm). Taken together, these findings demonstrate the importance of scaffold micro-architecture in the development of advanced tissue engineering strategies for articular cartilage defect repair.
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Cites
Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies
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Self-citationAdult mesenchymal stem cells for tissue engineering versus regenerative medicine
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The effect of pore size on cell adhesion in collagen-GAG scaffolds
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Identification of a novel population of muscle stem cells in mice
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Effect of Pore Size and Void Fraction on Cellular Adhesion, Proliferation, and Matrix Deposition
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Bone regeneration by implantation of purified, culture‐expanded human mesenchymal stem cells
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Cited by
Recent advances in bioprinting techniques: approaches, applications and future prospects
Li, J., Chen, M., Fan, X., & Zhou, H. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1028-0 · Cited by 608
Amani, H., Arzaghi, H., Bayandori, M., Dezfuli, A. S., Pazoki‐Toroudi, H., Shafiee, A., & Moradi, L. (2019) · Advanced Materials Interfaces · doi:10.1002/admi.201900572 · Cited by 436
Metadata
- Authors
- Matsiko, A., Gleeson, J. P., & O'Brien, F. J.
- Venue
- Tissue Engineering Part A
- Publisher
- SAGE Publications
- Published
- 2015-02
- Volume
- 21
- Issue
- 3-4
- Pages
- 486-497
- ISSN
- 1937-3341 (ISSN-L)
- 1937-335X
- OpenAlex
- W1427363165
- Cited by
- 259
- References
- 45
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- gold
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- Matsiko, A., Gleeson, J. P., & O'Brien, F. J. (2015). Scaffold Mean Pore Size Influences Mesenchymal Stem Cell Chondrogenic Differentiation and Matrix Deposition. Tissue Engineering Part A. https://doi.org/10.1089/ten.tea.2013.0545
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
