The Measurement of Fecal Thyroxine in the Diagnosis of Thyrotoxicosis Factitia
Abstract
Two patients with prolonged thyrotoxicosis are presented with low radioiodide uptake, low-normal serum thyroglobulin concentrations, and low iodide content of the neck on x-ray fluorescence studies. The surreptitious intake of thyroid hormone was directly proven by a high fecal concentration of T4 (12.38 and 23.99 nmol/g) compared with low concentrations in healthy subjects (1.03 +/- 0.64 nmol/g; mean +/- SD, n = 6) and in patients with hyperthyroidism due to Graves' disease (1.93 +/- 1.86; n = 8). Fecal thyroid hormone measurement may help to provide formal proof of factitious thyrotoxicosis.
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Fecal levothyroxine has been measured as a means of distinguishing surreptitious use of thyroid hormone from painless thyroiditis.
“Fecal levothy-roxine has been measured as a means of distinguishing surreptitious use of thyroid hormone from painless thyroiditis (54).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [54]
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References 8 · Cited by 29
- Authors
- BOUILLON, R., VERRESEN, L., STAELS, F., BEX, M., DE VOS, P., & DE ROO, M.
- Affiliations
- KU Leuven (BE)
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 1993-01
- Volume
- 3
- Issue
- 2
- Pages
- 101-103
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W1988117134
- Cited by
- 29
- References
- 8
- Citations by year
- 2026: 2 · 2025: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thyroid (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
- Keywords
- thyrotoxicosis factitia, thyroxine measurement, serum thyroglobulin, Graves' disease, hyperthyroidism diagnosis
- MeSH terms
- Adult, Feces, Female, Humans, Iodine, Middle Aged, Thyroglobulin, Thyrotoxicosis, Thyroxine, Reproducibility of Results, Biomarkers
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