The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Two Simple Methods for Measuring Iodine in Urine
Abstract
Urinary iodine excretion is currently the most convenient laboratory marker of iodine deficiency. Accelerating international interest in correcting this condition demands rapid, simple methods for assessment and monitoring. We describe two adaptations of the Sandell-Kolthoff reaction, in which urine is first digested with chloric acid and iodine then determined from its catalytic reduction of ceric ammonium sulfate in the presence of arsenious acid. Both methods use gentle digestion by chloric acid in a heating block. Method A detects iodine in a colorimeter, method B by the indicator ferroin and a stopwatch. Results with 12 samples ranging from 1.8 to 19.0 micrograms/dL (0.14-1.48 mumol/L) differed from those in a reference laboratory by a mean of 9.1% for method A and 15.7% for method B. One technician can perform at least 150 tests per day at a total cost of less than $0.50 each. The speed, low cost, and simple instrumentation make these methods well suited to epidemiological assessment of iodine deficiency in developing countries.
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Citations
Cites
Micro determination of iodine by a catalytic method
Sandell, E. B., & Kolthoff, I. M. (1937) · Mikrochimica Acta · doi:10.1007/bf01476194 · Cited by 590
Protein-Bound Iodine, Total Iodine, and Butanol-extractable Iodine by Partial Automation
Benotti, J., & Benotti, N. (1963) · Clinical Chemistry · doi:10.1093/clinchem/9.4.408 · Cited by 212
Determination of Total Iodine in Urine, Stool, Diets, and Tissue
Benotti, J. R., Benotti, N., Pino, S., & Gardyna, H. (1965) · Clinical Chemistry · doi:10.1093/clinchem/11.10.932 · Cited by 139
The Iodine Deficiency Disorders: Their Nature and Prevention
Hetzel, B. S., & Dunn, J. T. (1989) · Annual Review of Nutrition · doi:10.1146/annurev.nu.09.070189.000321 · Cited by 117
Self-citationVought, R. L., London, W. T., Lutwak, L., & Dublin, T. D. (1963) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-23-12-1218 · Cited by 87
Jolín, T., & del Rey, F. E. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-4-540 · Cited by 49
Iodine Deficiency — The Next Target for Elimination?
Dunn, J. T. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201233260411 · Cited by 43
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Cited by
The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey
Vanderpump, M. P. J., Tunbrldge, W. M. G., French, J. M., Appleton, D., Bates, D., Clark, F., Evans, J. G., Hasan, D. M., Rodgers, H., Tunbridge, F., et al. (1995) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1995.tb01894.x · Cited by 2,432
Hynes, K. L., Otahal, P., Hay, I., & Burgess, J. R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4249 · Cited by 296
Guan, H., Shan, Z., Teng, X., Li, Y., Teng, D., Jin, Y., Yu, X., Fan, C., Chong, W., Yang, F., et al. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03150.x · Cited by 88
Hintze, G., Blombach, O., Fink, H., Burkhardt, U., & Kobberling, J. (1999) · European Journal of Endocrinology · doi:10.1530/eje.0.1400264 · Cited by 84
Metadata
- Authors
- DUNN, J. T., CRUTCHFIELD, H. E., GUTEKUNST, R., & DUNN, A. D.
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 1993-01
- Volume
- 3
- Issue
- 2
- Pages
- 119-123
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W1965965147
- Cited by
- 349
- References
- 7
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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