Serum ghrelin levels in patients with Hashimoto's thyroiditis
Abstract
Objective Hypothyroidism is associated with changes in appetite and body weight. Ghrelin is an orexigenic peptide, and it stimulates appetite and increases food intake. However, the potential relationship between circulating ghrelin levels, hypothyroidism, and thyroid antibodies has not been adequately studied. Design Forty-seven patients with hypothyroidism due to Hashimoto's thyroiditis and 48 euthyroid subjects were enrolled in the study. Thyroid hormones and antibodies, insulin, glucose, ghrelin levels, and lipid parameters were measured in all the subjects. Main outcome Hypothyroid group showed significantly decreased serum levels of ghrelin and ghrelin=body mass index (BMI) compared to euthyroid group (31.9 +/- 21.5 pg/mL vs. 50.5 +/- 34.8 pg/mL, p Conclusion Thyroid hormones and antibodies seem to have a potential effect on serum ghrelin levels in patients with hypothyroidism.
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Conflicting reports have emerged regarding overt hypothyroidism-associated ghrelin concentration levels where it has been found to be either decreased, increased, or not affected.
“Conflicting reports have emerged regarding overt hypothyroidism-associated ghrelin concentration levels where it has been found to be either decreased (Altinova et al., 2006), increased (Gjedde et al., 2008), or not affected (Tanda et al., 2009).”
From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Altinova et al., 2006
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References 42 · Cited by 33
- Authors
- Altinova, A. E., Toruner, F., Karakoc, A., Yetkin, I., Ayvaz, G., Cakir, N., & Arslan, M.
- Affiliations
- Department of Endocrinology and Metabolism, Gazi University Medical Faculty, Ankara, Turkey.
- Gazi University (TR)
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2006-12
- Volume
- 16
- Issue
- 12
- Pages
- 1259-1264
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W2074537579
- Cited by
- 33
- References
- 42
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2021: 1 · 2018: 1 · 2017: 1 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thyroid (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- ghrelin, Hashimoto's thyroiditis, hypothyroidism, thyroid peroxidase antibodies, thyroglobulin antibodies, thyroid autoantibodies, body mass index, appetite, thyroid hormones, lipid profile, triglycerides, insulin resistance, antithyroid drug therapy
- MeSH terms
- Adult, Female, Humans, Hypothyroidism, Iodide Peroxidase, Male, Middle Aged, Thyroglobulin, Peptide Hormones, Hashimoto Disease, Ghrelin
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