Regulation of Tissue Iodothyronine Deiodinase Activity in a Model of Prolonged Critical Illness
Abstract
BACKGROUND: The low plasma triiodothyronine (T3) observed during prolonged critical illness can be explained in part by suppressed hepatic deiodinase type I (D1) and increased D3 activity. Infusion of thyrotropin-releasing hormone (TRH) can restore D1 and D3 activity in critically ill rabbits, but it remains unknown whether this is a direct effect of TRH or the TRH-induced rise in circulating thyroxine (T4) and T3. METHODS: To answer this specific question, burn-injured rabbits randomly received a 4-day treatment with saline, T4, T3, T4+T3, or TRH, started on day 4 of the illness. Plasma iodothyronine concentrations, D1 and D3 activity, and T3-responsive gene expression were quantified in liver and kidney. RESULTS: Infusion of T4, T3, or TRH increased circulating T3 levels and hepatic D1 activity. Co-infusion of T3 with T4 enhanced T4 to T3 conversion as demonstrated by lower T4, higher T3, and lower reverse T3 (rT3) levels and tended to further increase hepatic D1 activity. Hepatic D1 activity correlated positively with circulating T3 and the T3/rT3 ratio, but not with T4, rT3, or thyroid-stimulating hormone. CONCLUSIONS: During prolonged critical illness, D1 activity is primarily regulated via changes in circulating T3, suggesting that the low plasma T3 concentrations may be important in sustaining low D1 activity in this condition.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Illness results in marked downregulation of liver DIO1 both in humans and experimental animals.
“Illness results in marked downregulation of DIO1 both in humans and experimental animals [15, 20, 21].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [21]
Liver DIO3 is differentially regulated during illness: acute inflammation in mice results in decreased DIO3 levels but prolonged critical illness, both in patients and in rabbits, increases DIO3.
“Liver DIO3 is differentially regulated during illness: acute inflammation in mice results in decreased DIO3 levels [15] but prolonged critical illness, both in patients and in rabbits, increases DIO3 [21, 22].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [21]
The citation lists haven’t been fetched yet
References 76 · Cited by 50
- Authors
- Debaveye, Y., Ellger, B., Mebis, L., Darras, V. M., & Van den Berghe, G.
- Affiliations
- KU Leuven (BE)
- University Hospital Münster (DE)
- Department of Intensive Care Medicine, Catholic University of Leuven, Leuven, Belgium.
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2008-05
- Volume
- 18
- Issue
- 5
- Pages
- 551-560
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W2014303035
- Cited by
- 50
- References
- 76
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thyroid (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion)
- Funders
- UCB Pharma
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- iodothyronine deiodinase, type 3 deiodinase, triiodothyronine, thyroxine, reverse T3, thyrotropin-releasing hormone, burns, critical illness, hepatic deiodination, thyroid hormone regulation, liver, kidney, rabbits
- MeSH terms
- Animals, Disease Models, Animal, Iodide Peroxidase, Kidney, Liver, Male, Molecular Sequence Data, Rabbits, Thyrotropin-Releasing Hormone, Thyroxine, Triiodothyronine, Critical Illness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
