The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Prognostic Factors Affecting Neck Lymph Node Recurrence and Distant Metastasis in Papillary Microcarcinoma of the Thyroid: Results of a Study in 445 Patients
Abstract
BACKGROUND: The management of thyroid papillary microcarcinoma (PMC) is controversial. Total thyroidectomy, thyroid lobectomy/isthmectomy, and even no treatment have been proposed. We investigated the clinical course and prognostic factors for disease recurrence and distant metastasis in 445 patients with PMC. METHODS: Data from 445 patients diagnosed with PMC in the period from 1978 to 2003 were reviewed and analyzed. Total thyroidectomy was performed in 404 patients and loboisthmusectomy in 41. Neck dissection took place in 226 patients (49.7%), with 166 of only the central compartment and 60 of both the central and lateral compartments. Radioiodine ((131)I) ablation treatment was given to 389 patients. RESULTS: Median tumor size was 7 mm (range 1-10 mm). PMC was multifocal in 156 cases (35%) and bilateral in 60 cases (13.5%). Extrathyroidal tumor extension (pT3) and neck lymph node metastasis (pN1) were present in 133 (30%) and 182 (40.9%) patients, respectively. Capsular invasion without extrathyroidal tumor extension was observed in 39 (8.7%) patients. Mean follow-up was 5.3 (range 1-26) years. Seventeen (3.8%) patients had recurrence or persistence of disease: neck recurrence (NR) in 12 (2.7%), distant metastasis (DM) in four (0.9%), NR + DM in one (0.2%). One patient (0.2%) died of the disease. Capsular invasion, extrathyroidal tumor extension (pT3), and neck lymph node metastasis at presentation (pN1) were the only independent risk factors for NR and/or DM occurrence (p < 0.05). Patients not showing these features, who were treated with loboisthmusectomy only, never experienced disease recurrence. CONCLUSION: Total thyroidectomy seems advisable in PMC with extrathyroidal extension and neck lymph node metastasis at presentation. Capsular invasion without extrathyroidal extension may suggest aggressive tumor behavior and require radical treatment.
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Haugen, B. R., Alexander, E. K., Bible, K. C., Doherty, G. M., Mandel, S. J., Nikiforov, Y. E., Pacini, F., Randolph, G. W., Sawka, A. M., Schlumberger, M., et al. (2016) · Thyroid® · doi:10.1089/thy.2015.0020 · Cited by 16,535
Cooper, D. S., Doherty, G. M., Haugen, B. R., Kloos, R. T., Lee, S. L., Mandel, S. J., Mazzaferri, E. L., McIver, B., Sherman, S. I., & Tuttle, R. M. (2006) · Thyroid · doi:10.1089/thy.2006.16.109 · Cited by 2,016
Pacini, F., Schlumberger, M., Dralle, H., Elisei, R., Smit, J. W. A., Wiersinga, W., & _, _. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02158 · Cited by 1,976
Hundahl, S. A., Fleming, I. D., Fremgen, A. M., & Menck, H. R. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19981215)83:12<2638::aid-cncr31>3.0.co;2-1 · Cited by 1,836
Robbins, K. T., Clayman, G., Levine, P. A., Medina, J., Sessions, R., Shaha, A., Som, P., & Wolf, G. T. (2002) · Archives of Otolaryngology–Head & Neck Surgery · doi:10.1001/archotol.128.7.751 · Cited by 1,012
Occult papillary carcinoma of the thyroid. A “normal” finding in finland. A systematic autopsy study
Harach, H. R., Franssila, K. O., & Wasenius, V.-M. (1985) · Cancer · doi:10.1002/1097-0142(19850801)56:3<531::aid-cncr2820560321>3.0.co;2-3 · Cited by 945
Papillary thyroid microcarcinoma: A study of 900 cases observed in a 60-year period
Hay, I. D., Hutchinson, M. E., Gonzalez-Losada, T., McIver, B., Reinalda, M. E., Grant, C. S., Thompson, G. B., Sebo, T. J., & Goellner, J. R. (2008) · Surgery · doi:10.1016/j.surg.2008.08.035 · Cited by 940
Chow, S., Law, S. C. K., Chan, J. K. C., Au, S., Yau, S., & Lau, W. (2003) · Cancer · doi:10.1002/cncr.11442 · Cited by 723
Mazzaferri, E. L., Robbins, R. J., Spencer, C. A., Braverman, L. E., Pacini, F., Wartofsky, L., Haugen, B. R., Sherman, S. I., Cooper, D. S., Braunstein, G. D., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021702 · Cited by 654
Sawka, A. M., Thephamongkhol, K., Brouwers, M., Thabane, L., Browman, G., & Gerstein, H. C. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031167 · Cited by 432
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Guidelines for the management of thyroid cancer
Perros, P., Boelaert, K., Colley, S., Evans, C., Evans, R. M., Gerrard BA, G., Gilbert, J., Harrison, B., Johnson, S. J., Giles, T. E., et al. (2014) · Clinical Endocrinology · doi:10.1111/cen.12515 · Cited by 1,372
Shin, J. H., Baek, J. H., Chung, J., Ha, E. J., Kim, J.-H., Lee, Y. H., Lim, H. K., Moon, W.-J., Na, D. G., Park, J. S., et al. (2016) · Korean Journal of Radiology · doi:10.3348/kjr.2016.17.3.370 · Cited by 889
for the German Societies of General and Visceral Surgery; Endocrinology; Nuclear Medicine; Pathology; Radiooncology; Oncological Hematology; and the German Thyroid Cancer Patient Support Organization Ohne Schilddrüse leben e.V., Dralle, H., Musholt, T. J., Schabram, J., Steinmüller, T., Frilling, A., Simon, D., Goretzki, P. E., Niederle, B., Scheuba, C., et al. (2013) · Langenbeck's Archives of Surgery · doi:10.1007/s00423-013-1057-6 · Cited by 279
Metadata
- Authors
- Mercante, G., Frasoldati, A., Pedroni, C., Formisano, D., Renna, L., Piana, S., Gardini, G., Valcavi, R., & Barbieri, V.
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2009-07
- Volume
- 19
- Issue
- 7
- Pages
- 707-716
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W1992679238
- Cited by
- 259
- References
- 22
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mercante, G., Frasoldati, A., Pedroni, C., Formisano, D., Renna, L., Piana, S., Gardini, G., Valcavi, R., & Barbieri, V. (2009). Prognostic Factors Affecting Neck Lymph Node Recurrence and Distant Metastasis in Papillary Microcarcinoma of the Thyroid: Results of a Study in 445 Patients. Thyroid. https://doi.org/10.1089/thy.2008.0270
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