The DOI matches its Crossref record.
On Chikungunya Acute Infection and Chloroquine Treatment
Open accessAbstract
In recent issues, the efficacy of chloroquine (and the dosage that may be used) in the treatment of acute chikungunya infections was discussed. We have conducted a double-blind placebo-controlled randomized trial on the French Reunion Island (Indian Ocean), in which 27 patients received chloroquine and 27 patients received a placebo treatment. The chloroquine treatment consisted of 600 mg at day 1, 600 mg at days 2 and 3, and 300 mg at days 4 and 5. No significant difference between groups could be identified regarding the duration of febrile arthralgia or the decrease of viremia between day 1 and day 3. However, at day 200, patients who received chloroquine complained more frequently of arthralgia than those who received placebo (p < 0.01). In conclusion, our results suggest that there is currently no justification for the use of chloroquine to treat acute chikungunya infections.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Al-Bari, M. A. A. (2017) · Pharmacology Research & Perspectives · doi:10.1002/prp2.293 · Cited by 382
A Randomized Controlled Trial of Chloroquine for the Treatment of Dengue in Vietnamese Adults
Tricou, V., Minh, N. N., Van, T. P., Lee, S. J., Farrar, J., Wills, B., Tran, H. T., & Simmons, C. P. (2010) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0000785 · Cited by 329
Chandler, L., Yusuf, I., McClements, M., Barnard, A., MacLaren, R., & Xue, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144972 · Cited by 49
Metadata
- Authors
- Lamballerie, X. D., Boisson, V., Reynier, J.-C., Enault, S., Charrel, R. N., Flahault, A., Roques, P., & Grand, R. L.
- Venue
- Vector-Borne and Zoonotic Diseases
- Publisher
- SAGE Publications
- Published
- 2008-12
- Volume
- 8
- Issue
- 6
- Pages
- 837-840
- ISSN
- 1530-3667 (ISSN-L)
- 1557-7759
- OpenAlex
- W2032559848
- Cited by
- 245
- References
- 0
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: On Chikungunya Acute Infection and Chloroquine Treatment. https://app.cochat.ai/papers/10.1089/vbz.2008.0049
- The paper
- Lamballerie, X. D., Boisson, V., Reynier, J.-C., Enault, S., Charrel, R. N., Flahault, A., Roques, P., & Grand, R. L. (2008). On Chikungunya Acute Infection and Chloroquine Treatment. Vector-Borne and Zoonotic Diseases. https://doi.org/10.1089/vbz.2008.0049
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
