The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Laminins: Roles and Utility in Wound Repair
Open accessAbstract
Significance: Laminins are complex extracellular macromolecules that are major players in the control of a variety of core cell processes, including regulating rates of cell proliferation, differentiation, adhesion, and migration. Laminins, and related extracellular matrix components, have essential roles in tissue homeostasis; however, during wound healing, the same proteins are critical players in re-epithelialization and angiogenesis. Understanding how these proteins influence cell behavior in these different conditions holds great potential in identifying new strategies to enhance normal wound closure or to treat chronic/nonhealing wounds. Recent Advances: Laminin-derived bioactive peptides and, more recently, laminin-peptide conjugated scaffolds, have been designed to improve tissue regeneration after injuries. These peptides have been shown to be effective in decreasing inflammation and granulation tissue, and in promoting re-epithelialization, angiogenesis, and cell migration. Critical Issues: Although there is now a wealth of knowledge concerning laminin form and function, there are still areas of some controversy. These include the relative contribution of two laminin-based adhesive devices (focal contacts and hemidesmosomes) to the re-epithelialization process, the impact and implications of laminin proteolytic processing, and the importance of laminin polymer formation on cell behavior. In addition, the roles in wound healing of the laminin-related proteins, netrins, and LaNts are still to be fully defined. Future Directions: The future of laminin-based therapeutics potentially lies in the bioengineering of specific substrates to support laminin deposition for ex vivo expansion of autologous cells for graft formation and transplantation. Significant recent advances suggest that this goal is within sight.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Keratinocytes themselves further activate fibroblasts in a feedback loop through the production of fibronectin, tenascin C, and laminin 332 (Fig. 2) [93].”
From Immunology of Wound Healing (2018) · cites this paper as [93]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A simplified laminin nomenclature
Aumailley, M., Bruckner‐Tuderman, L., Carter, W. G., Deutzmann, R., EDGAR, D., Ekblom, P., Engel, J., Engvall, E., Hohenester, E., & Jones, J. (2005) · Matrix Biology · doi:10.1016/j.matbio.2005.05.006 · Cited by 928
Beningo, K. A., Dembo, M., Kaverina, I., Small, J. V., & Wang, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.4.881 · Cited by 750
Supramolecular assembly of basement membranes
Timpl, R., & Brown, J. C. (1996) · BioEssays · doi:10.1002/bies.950180208 · Cited by 701
Miner, J. H., Patton, B. L., Lentz, S. I., Gilbert, D. J., Snider, W. D., Jenkins, N. A., Copeland, N. G., & Sanes, J. R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.3.685 · Cited by 650
Expression and Function of Laminins in the Embryonic and Mature Vasculature
Hallmann, R., Horn, N., Selg, M., Wendler, O., Pausch, F., & Sorokin, L. M. (2005) · Physiological Reviews · doi:10.1152/physrev.00014.2004 · Cited by 597
Miner, J. H., Cunningham, J. M., & Sanes, J. R. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.6.1713 · Cited by 491
Laminins in basement membrane assembly
Hohenester, E., & Yurchenco, P. D. (2013) · Cell Adhesion & Migration · doi:10.4161/cam.21831 · Cited by 478
Laminin-nidogen complex. Extraction with chelating agents and structural characterization
Paulsson, M., Aumailley, M., Deutzmann, R., Timpl, R., Beck, K., & ENGEL, J. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb13476.x · Cited by 450
Functional Diversity of Laminins
Domogatskaya, A., Rodin, S., & Tryggvason, K. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155750 · Cited by 396
Deletion of the Laminin α4 Chain Leads to Impaired Microvessel Maturation
Thyboll, J., Kortesmaa, J., Cao, R., Soininen, R., Wang, L., Iivanainen, A., Sorokin, L. M., Risling, M., Cao, Y., & Tryggvason, K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1194-1202.2002 · Cited by 349
Cited by
Sorted by citations
Extracellular matrix structure
Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.001 · Cited by 2,598
Extracellular matrix and its therapeutic potential for cancer treatment
Huang, J., Zhang, L., Wan, D., Zhou, L., Zheng, S., Lin, S., & Qiao, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00544-0 · Cited by 962
Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies
Rousselle, P., Braye, F., & Dayan, G. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.06.019 · Cited by 679
Ellis, S., Lin, E. J., & Tartar, D. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0234-9 · Cited by 625
Experimental models and methods for cutaneous wound healing assessment
Masson‐Meyers, D. S., de Andrade, T. A. M., Caetano, G. F., Guimarães, F. R., Leite, M. N., Leite, S. N., & Frade, M. A. C. (2020) · International Journal of Experimental Pathology · doi:10.1111/iep.12346 · Cited by 560
Metadata
- Authors
- Iorio, V., Troughton, L. D., & Hamill, K. J.
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Hamill, Kevin J.
- Venue
- Advances in Wound Care
- Publisher
- SAGE Publications
- Published
- 2015-04
- Volume
- 4
- Issue
- 4
- Pages
- 250-263
- ISSN
- 2162-1918 (ISSN-L)
- 2162-1934
- PMC
- PMC4397997
- OpenAlex
- W2315246287
- Cited by
- 169
- References
- 120
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 23 · 2023: 23 · 2022: 13 · 2021: 17 · 2020: 23 · 2019: 8 · 2018: 16 · 2017: 12 · 2016: 6 · 2015: 3
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in Wound Care (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- British Skin Foundation
- University of Liverpool
- Biotechnology and Biological Sciences Research Council (BB/L020513/1)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- laminin, wound healing, re-epithelialization, angiogenesis, chronic wounds, focal adhesions, hemidesmosomes, netrin, cell migration, cell adhesion, tissue regeneration, ex vivo cell expansion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
