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Lamin-dependent Localization of UNC-84, A Protein Required for Nuclear Migration in Caenorhabditis elegans
Open accessAbstract
Mutations in the Caenorhabditis elegans unc-84 gene cause defects in nuclear migration and anchoring. We show that endogenous UNC-84 protein colocalizes with Ce-lamin at the nuclear envelope and that the envelope localization of UNC-84 requires Ce-lamin. We also show that during mitosis, UNC-84 remains at the nuclear periphery until late anaphase, similar to known inner nuclear membrane proteins. UNC-84 protein is first detected at the 26-cell stage and thereafter is present in most cells during development and in adults. UNC-84 is properly expressed in unc-83 andanc-1 lines, which have phenotypes similar tounc-84, suggesting that neither the expression nor nuclear envelope localization of UNC-84 depends on UNC-83 or ANC-1 proteins. The envelope localization of Ce-lamin, Ce-emerin, Ce-MAN1, and nucleoporins are unaffected by the loss of UNC-84. UNC-84 is not required for centrosome attachment to the nucleus because centrosomes are localized normally in unc-84 hyp7 cells despite a nuclear migration defect. Models for UNC-84 localization are discussed.
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Cited by
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Metadata
- Authors
- Lee, K. K., Starr, D., Cohen, M., Liu, J., Han, M., Wilson, K. L., & Gruenbaum, Y.
- Venue
- Molecular Biology of the Cell
- Published
- 2002-03
- Volume
- 13
- Issue
- 3
- Pages
- 892-901
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2104012781
- Cited by
- 165
- References
- 0
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, K. K., Starr, D., Cohen, M., Liu, J., Han, M., Wilson, K. L., & Gruenbaum, Y. (2002). Lamin-dependent Localization of UNC-84, A Protein Required for Nuclear Migration in Caenorhabditis elegans. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.01-06-0294
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