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Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.
Open accessAbstract
Focal adhesion kinase (pp125FAK or FAK) and paxillin colocalize with integrins in structures called focal adhesions. pp125FAK plays an important role in the transmission of integrin-induced cytoplasmic signals. Paxillin has also been implicated in cell signaling by virtue of its association with the protein tyrosine kinases pp60src and Csk (C-terminal Src kinase) as well as with the adapter/oncoprotein p47gag-crk. In this report we show that endogenous pp125FAK and paxillin form a stable complex both in vivo and in vitro and that this interaction is direct, requiring only pp125FAK and paxillin. The paxillin binding site on pp125FAK has been localized to the carboxy-terminal 148 residues of pp125FAK, but appears to be distinct from the previously identified focal adhesion-targeting sequence also present in the carboxy-terminal domain of pp125FAK. The interaction of paxillin and pp125FAK is independent of the adhesion of cells to the extracellular matrix, as the association can be detected in suspension cells as well as those attached to fibronectin.
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Cites
Signal transduction from the extracellular matrix.
Juliano, R. L., & Haskill, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.3.577 · Cited by 1,683
Cited by
Focal adhesion kinase: the first ten years
Parsons, J. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00373 · Cited by 1,373
Self-citationRequired role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
Sieg, D. J., Hauck, C. R., & Schlaepfer, D. D. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.16.2677 · Cited by 687
Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.
Schaller, M. D., Otey, C. A., Hildebrand, J. D., & Parsons, J. T. (1995) · The Journal of cell biology · doi:10.1083/jcb.130.5.1181 · Cited by 622
Self-citationGilmore, A. P., & Romer, L. H. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.8.1209 · Cited by 513
Signaling through focal adhesion kinase
Hanks, S. K., & Polte, T. R. (1997) · BioEssays · doi:10.1002/bies.950190208 · Cited by 469
Metadata
- Authors
- Hildebrand, J. D., Schaller, M. D., & Parsons, J. T.
- Venue
- Molecular Biology of the Cell
- Published
- 1995-06
- Volume
- 6
- Issue
- 6
- Pages
- 637-647
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2156451315
- Cited by
- 341
- References
- 1
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Hildebrand, J. D., Schaller, M. D., & Parsons, J. T. (1995). Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.6.6.637
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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