The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Highly Stoichiometric, Stable, and Specific Association of Integrin α3β1 with CD151 Provides a Major Link to Phosphatidylinositol 4-Kinase, and May Regulate Cell Migration
Open accessAbstract
Here we describe an association between α3β1 integrin and transmembrane-4 superfamily (TM4SF) protein CD151. This association is maintained in relatively stringent detergents and thus is remarkably stable in comparison with previously reported integrin–TM4SF protein associations. Also, the association is highly specific (i.e., observed in vitro in absence of any other cell surface proteins), and highly stoichiometric (nearly 90% of α3β1 associated with CD151). In addition, α3β1 and CD151 appeared in parallel on many cell lines and showed nearly identical skin staining patterns. Compared with other integrins, α3β1 exhibited a considerably higher level of associated phosphatidylinositol-4-kinase (PtdIns 4-kinase) activity, most of which was removed upon immunodepletion of CD151. Specificity for CD151 and PtdIns 4-kinase association resided in theextracellular domain of α3β1, thus establishing a novel paradigm for the specific recruitment of anintracellular signaling molecule. Finally, antibodies to either CD151 or α3β1 caused a ∼88–92% reduction in neutrophil motility in response to f-Met-Leu-Phe on fibronectin, suggesting an functionally important role of these complexes in cell migration.
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Cited by
Tetraspanin functions and associated microdomains
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Self-citationIntegrins as receptors for laminins
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Self-citationJouannet, S., Saint-Pol, J., Fernandez, L., Nguyen, V., Charrin, S., Boucheix, C., Brou, C., Milhiet, P.-E., & Rubinstein, E. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2111-z · Cited by 138
Tetraspanin12 regulates ADAM10‐dependent cleavage of amyloid precursor protein
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Metadata
- Authors
- Yauch, R. L., Berditchevski, F., Harler, M. B., Reichner, J., & Hemler, M. E.
- Venue
- Molecular Biology of the Cell
- Published
- 1998-10
- Volume
- 9
- Issue
- 10
- Pages
- 2751-2765
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2161799300
- Cited by
- 316
- References
- 51
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Highly Stoichiometric, Stable, and Specific Association of Integrin α3β1 with CD151 Provides a Major Link to Phosphatidylinositol 4-Kinase, and May Regulate Cell Migration. https://app.cochat.ai/papers/10.1091/mbc.9.10.2751
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- Yauch, R. L., Berditchevski, F., Harler, M. B., Reichner, J., & Hemler, M. E. (1998). Highly Stoichiometric, Stable, and Specific Association of Integrin α3β1 with CD151 Provides a Major Link to Phosphatidylinositol 4-Kinase, and May Regulate Cell Migration. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.9.10.2751
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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